The potential utilizations of hydrogen as a promising therapeutic strategy against ocular diseases

Hydrogen, one of the most well-known natural molecules, has been used in numerous medical applications owing to its ability to selectively neutralize cytotoxic reactive oxygen species and ameliorate hazardous inflammations. Hydrogen can exert protective effects on various reactive oxygen species-rel...

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Bibliographic Details
Published in:Therapeutics and clinical risk management 2016-01, Vol.12 (Issue 1), p.799-806
Main Authors: Tao, Ye, Geng, Lei, Xu, Wei-Wei, Qin, Li-Min, Peng, Guang-Hua, Huang, Yi-Fei
Format: Article
Language:English
Subjects:
Antioxidants
Apoptosis
Care and treatment
Cataracts
Cell cycle
Clinical medicine
Cornea
Cytotoxicity
Deoxyribonucleic acid
Diabetes
Diabetic retinopathy
DNA
Eye diseases
Eye surgery
Glaucoma
Hydrogen
Injuries
Ischemia
Macular degeneration
Metabolism
ocular diseases
Optic nerve
Oxidative stress
Physiology
Retina
Review
therapeutic strategy
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Summary:Hydrogen, one of the most well-known natural molecules, has been used in numerous medical applications owing to its ability to selectively neutralize cytotoxic reactive oxygen species and ameliorate hazardous inflammations. Hydrogen can exert protective effects on various reactive oxygen species-related diseases, including the transplantation-induced intestinal graft injury, chronic inflammation, ischemia-reperfusion injuries, and so on. Especially in the eye, hydrogen has been used to counteract multiple ocular pathologies in the ophthalmological models. Herein, the ophthalmological utilizations of hydrogen are systematically reviewed and the underlying mechanisms of hydrogen-induced beneficial effects are discussed. It is our hope that the protective effects of hydrogen, as evidenced by these pioneering studies, would enrich our pharmacological knowledge about this natural element and cast light into the discovery of a novel therapeutic strategy against ocular diseases.
ISSN:1176-6336
1178-203X
1178-203X
DOI:10.2147/TCRM.S102518