The Promising Role of Antioxidant Phytochemicals in the Prevention and Treatment of Periodontal Disease via the Inhibition of Oxidative Stress Pathways: Updated Insights

There is growing evidence on the involvement of oxidative stress, which is simply described as the imbalance between oxidants and antioxidants in favor of the former, in the development of periodontal disease that is the most common inflammatory disease in the oral cavity. Thus, the potential of ant...

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Bibliographic Details
Published in:Antioxidants 2020-12, Vol.9 (12), p.1211
Main Authors: Vo, Thi Thuy Tien, Chu, Pei-Ming, Tuan, Vo Phuoc, Te, Joyce Si-Liang, Lee, I-Ta
Format: Article
Language:English
Subjects:
antioxidant
Antioxidants
Biofilms
Cytokines
Dental plaque
Diabetes
Disease prevention
Herbal medicine
Illnesses
Immune system
Inflammation
Inflammatory diseases
Microorganisms
Oral cavity
Oxidants
Oxidative stress
Pathogenesis
Pathogens
periodontal disease
Periodontal diseases
Periodontium
Physiology
Phytochemicals
Review
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Summary:There is growing evidence on the involvement of oxidative stress, which is simply described as the imbalance between oxidants and antioxidants in favor of the former, in the development of periodontal disease that is the most common inflammatory disease in the oral cavity. Thus, the potential of antioxidant phytochemicals as adjunctively preventive and therapeutic agents against the initiation and progression of periodontal disease is a topic of great interest. The current review firstly aims to provide updated insights about the immuno-inflammatory pathway regulated by oxidative stress in periodontal pathology. Then, this work further presents the systemic knowledge of antioxidant phytochemicals, particularly the pharmacological activities, which can be utilized in the prevention and treatment of periodontal disease. Additionally, the challenges and future prospects regarding such a scope are figured out.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox9121211