The Role of Diabetic Choroidopathy in the Pathogenesis and Progression of Diabetic Retinopathy

Diabetic choroidopathy was first described on histopathological specimens of diabetic eyes. This alteration was characterized by the accumulation of PAS-positive material within the intracapillary stroma. Inflammation and polymorphonuclear neutrophils (PMNs) activation are crucial elements in chorio...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-06, Vol.24 (12), p.10167
Main Authors: Scuderi, Luca, Fragiotta, Serena, Di Pippo, Mariachiara, Abdolrahimzadeh, Solmaz
Format: Article
Language:English
Subjects:
Angiography
Angiography - methods
B cells
Cell activation
choriocapillaris
choroid
Choroid - blood supply
Development and progression
Diabetes
Diabetes mellitus
Diabetes Mellitus - pathology
diabetic choroidopathy
Diabetic retinopathy
Diabetic Retinopathy - etiology
Diabetic Retinopathy - pathology
Enzymes
Fluorescein Angiography - methods
Humans
Immunology
Inflammation
Leukocytes (neutrophilic)
Leukocytes (polymorphonuclear)
Medical imaging
Nitric oxide
optical coherence tomography
Pathogenesis
Photoreceptors
Qualitative analysis
Retina - pathology
Retinal Vessels - pathology
Retinopathy
Review
Stroma
Tomography, Optical Coherence - methods
Veins & arteries
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Summary:Diabetic choroidopathy was first described on histopathological specimens of diabetic eyes. This alteration was characterized by the accumulation of PAS-positive material within the intracapillary stroma. Inflammation and polymorphonuclear neutrophils (PMNs) activation are crucial elements in choriocapillaris impairment. The evidence of diabetic choroidopathy in vivo was confirmed with multimodal imaging, which provides key quantitative and qualitative features to characterize the choroidal involvement. The choroid can be virtually affected in each vascular layer, from Haller's layer to the choriocapillaris. However, the damage on the outer retina and photoreceptor cells is essentially driven by a choriocapillaris deficiency, which can be assessed through optical coherence tomography angiography (OCTA). The identification of characteristic features of diabetic choroidopathy can be significant for understanding the potential pathogenic and prognostic implications in diabetic retinopathy.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms241210167