The Phytochemical Potential for Brain Disease Therapy and the Possible Nanodelivery Solutions for Brain Access

Plant-derived phytochemicals have gifted humans with vast therapeutic potentials. Yet, the unique features of the blood-brain barrier significantly limit their accession to the target tissue and thus clinical translation in brain disease treatment. Herein, we explore the medicinal outcomes of both t...

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Bibliographic Details
Published in:Frontiers in oncology 2022-06, Vol.12, p.936054
Main Authors: Liu, Yang, Chen, Zhouchun, Li, Aijie, Liu, Runhan, Yang, Haoying, Xia, Xue
Format: Article
Language:English
Subjects:
blood–brain barrier
brain diseases
nanodelivery
Oncology
phytochemicals
therapeutics development
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Summary:Plant-derived phytochemicals have gifted humans with vast therapeutic potentials. Yet, the unique features of the blood-brain barrier significantly limit their accession to the target tissue and thus clinical translation in brain disease treatment. Herein, we explore the medicinal outcomes of both the rare examples of phytochemicals that can easily translocate across the blood-brain barrier and most of the phytochemicals that were reported with brain therapeutic effects, but a bizarre amount of dosage is required due to their chemical nature. Lastly, we offer the nanodelivery platform that is capable of optimizing the targeted delivery and application of the non-permeable phytochemicals as well as utilizing the permeable phytochemicals for boosting novel applications of nanodelivery toward brain therapies.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2022.936054