Sarcomatoid renal cell carcinoma: MRI features and their association with survival

To evaluate MRI features of sarcomatoid renal cell carcinoma (RCC) and their association with survival. This retrospective single-center study included 59 patients with sarcomatoid RCC who underwent MRI before nephrectomy during July 2003-December 2019. Three radiologists reviewed MRI findings of tu...

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Bibliographic Details
Published in:Cancer imaging 2023-02, Vol.23 (1), p.16-16, Article 16
Main Authors: Cheng, Monica, Duzgol, Cihan, Kim, Tae-Hyung, Ghafoor, Soleen, Becker, Anton S, Causa Andrieu, Pamela I, Gangai, Natalie, Jiang, Hui, Hakimi, Abraham A, Vargas, Hebert A, Woo, Sungmin
Format: Article
Language:English
Subjects:
Carcinoma, Renal cell
Carcinoma, Renal Cell - diagnostic imaging
Carcinoma, Renal Cell - pathology
Differentiation
Ethnicity
Female
Hazard identification
Humans
Ipilimumab
Kidney cancer
Kidney Neoplasms - diagnostic imaging
Kidney Neoplasms - pathology
Lymphatic system
Magnetic Resonance Imaging
Male
Medical research
Medicine, Experimental
Metastasis
Middle Aged
Multivariate analysis
Pathology
Patients
Prognosis
Regression models
Renal cell carcinoma
Retrospective Studies
Sarcoma
Sarcomatoid
Survival
Tumors
Variables
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Summary:To evaluate MRI features of sarcomatoid renal cell carcinoma (RCC) and their association with survival. This retrospective single-center study included 59 patients with sarcomatoid RCC who underwent MRI before nephrectomy during July 2003-December 2019. Three radiologists reviewed MRI findings of tumor size, non-enhancing areas, lymphadenopathy, and volume (and percentage) of T2 low signal intensity areas (T2LIA). Clinicopathological factors of age, gender, ethnicity, baseline metastatic status, pathological details (subtype and extent of sarcomatoid differentiation), treatment type, and follow-up were extracted. Survival was estimated using Kaplan-Meier method and Cox proportional-hazards regression model was used to identify factors associated with survival. Forty-one males and eighteen females (median age 62 years; interquartile range 51-68) were included. T2LIAs were present in 43 (72.9%) patients. At univariate analysis, clinicopathological factors associated with shorter survival were: greater tumor size (> 10 cm; HR [hazard ratio] = 2.44, 95% CI 1.15-5.21; p = 0.02), metastatic lymph nodes (present; HR = 2.10, 95% CI 1.01-4.37; p = 0.04), extent of sarcomatoid differentiation (non-focal; HR = 3.30, 95% CI 1.55-7.01; p 
ISSN:1470-7330
1740-5025
1470-7330
DOI:10.1186/s40644-023-00535-0