Immunoregulatory Role of the Mechanosensitive Ion Channel Piezo1 in Inflammation and Cancer

Piezo1 was originally identified as a mechanically activated, nonselective cation ion channel, with significant permeability to calcium ions, is evolutionally conserved, and is involved in the proliferation and development of various types of cells, in the context of various types of mechanical or i...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-12, Vol.28 (1), p.213
Main Authors: Wang, Yuexin, Zhang, Zhiyuan, Yang, Qiuli, Cao, Yejin, Dong, Yingjie, Bi, Yujing, Liu, Guangwei
Format: Article
Language:English
Subjects:
Amino acids
Blood pressure
Blood vessels
Bones
Calcium ions
Calcium permeability
Cancer
cancer immunotherapy
Cell proliferation
Endothelium
Immune system
immunity
Immunoregulation
Inflammation
Kinases
Lungs
mechanosensitive ion channel
Organisms
Permeability
Physiology
Piezo1
Proteins
Review
Tumors
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Summary:Piezo1 was originally identified as a mechanically activated, nonselective cation ion channel, with significant permeability to calcium ions, is evolutionally conserved, and is involved in the proliferation and development of various types of cells, in the context of various types of mechanical or innate stimuli. Recently, our study and work by others have reported that Piezo1 from all kinds of immune cells is involved in regulating many diseases, including infectious inflammation and cancer. This review summarizes the recent progress made in understanding the immunoregulatory role and mechanisms of the mechanical receptor Piezo1 in inflammation and cancer and provides new insight into the biological significance of Piezo1 in regulating immunity and tumors.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28010213