Pediatric focal segmental glomerulosclerosis in Jordan : a tertiary hospital experience

Our objective is to study the demographical data, clinical course and outcome of children with primary focal segmental glomerulosclerosis (FSGS) in Jordan. A retrospective chart review of patients with a diagnosis of FSGS at a tertiary care hospital from the period July 2010 to July 2016 was conduct...

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Bibliographic Details
Published in:Saudi journal of kidney diseases and transplantation 2018-07, Vol.29 (4), p.816-821
Main Authors: al-Rabadi, Katibah H., Farah, Mahdi Q., al-Saliata, Ghazi M., al-Baramki, Jumanah H., al-Mardini, Riham, al-Bdirat, Jwahir T.
Format: Article
Language:English
Subjects:
Analysis
Development and progression
Kidney diseases
Prevalence studies (Epidemiology)
Treatment outcome
الخبرة
المتلازمة الكلوية
المستشفيات
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Summary:Our objective is to study the demographical data, clinical course and outcome of children with primary focal segmental glomerulosclerosis (FSGS) in Jordan. A retrospective chart review of patients with a diagnosis of FSGS at a tertiary care hospital from the period July 2010 to July 2016 was conducted. A total of 99 patients were analyzed. The mean age of presentation was 3.71 ± 2.59 years, 66% were male. At presentation, 66.6% of patients were steroid-resistant, 10% had a steroid dependant course and 20.2% had familial FSGS. Cyclosporine was used in 66.6% of children with a response rate of 46.9%. Long-term follow-up showed complete remission in 29.3%, partial remission in 31.3%, end-stage renal disease in 22.2%, and death in 11.1%. There is a high prevalence of familial FSGS in our Jordanian cohort with a high rate of progression to end-stage kidney disease.
ISSN:1319-2442
2320-3838
DOI:10.4103/1319-2442.239655