Evidence of Extensive Circulation of Yersinia enterocolitica in Rodents and Shrews in Natural Habitats from Retrospective and Perspective Studies in South Caucasus

culture-positive rodents and shrews were reported in different territories across Georgia during 14 of 17 years of investigations conducted for the period of 1981-1997. In total, was isolated from 2052 rodents (15 species) and 33 shrews. Most isolates were obtained from , , , and spp. During the pro...

Full description

Saved in:
Bibliographic Details
Published in:Pathogens (Basel) 2021-07, Vol.10 (8), p.939
Main Authors: Imnadze, Tata, Malania, Lile, Chakvetadze, Neli, Burjanadze, Irma, Abazashvili, Natalia, Zhgenti, Ekaterine, Sidamonidze, Ketevan, Khmaladze, Ekaterine, Martashvili, Vakhtang, Tsertsvadze, Nikoloz, Imnadze, Paata, Kandaurov, Andrei, Arner, Ryan J, Motin, Vladimir, Kosoy, Michael
Format: Article
Language:English
Subjects:
Annual reports
Bacteria
bacterial genome
E coli
Ecology
Flagella
Food contamination & poisoning
Gene sequencing
Genes
Genomes
Heat-labile enterotoxin
heat-labile toxin
Homology
Laboratory animals
Nucleotides
Phylogeny
Plasmids
Polymorphism
Public health
Rodents
shrews
Single-nucleotide polymorphism
Small mammals
SNP-typing
Soricidae
Taxonomy
Virulence
Yersinia
Yersinia enterocolitica
Zoonoses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:culture-positive rodents and shrews were reported in different territories across Georgia during 14 of 17 years of investigations conducted for the period of 1981-1997. In total, was isolated from 2052 rodents (15 species) and 33 shrews. Most isolates were obtained from , , , and spp. During the prospective study (2017-2019), isolates of -like bacteria were cultured from 53 rodents collected in four parts of Georgia. All the -like isolates were confirmed as based on the API 20E and the BD Phenix50 tests. Whole-genome (WG) sequencing of five rodents and one shrew strain of revealed that they possessed a set of virulence genes characteristic of the potentially pathogenic strains of biogroup 1A. All isolates lacked distinguished virulence determinants for YstA, Ail, TccC, VirF, and virulence plasmid pYV but carried the genes for YstB, YmoA, HemPR-HmuVSTU, YaxAB, PhlA, PldA, ArsCBR, and a flagellar apparatus. One strain contained a gene highly homologous to heat-labile enterotoxin, a chain of , a function not previously described for . The WG single-nucleotide polymorphism-based typing placed the isolates in four distinct phylogenetic clusters.
ISSN:2076-0817
2076-0817
DOI:10.3390/pathogens10080939