Multimodal MRI for Estimating Her-2 Gene Expression in Endometrial Cancer

• Published in: Bioengineering (Basel) 2023-12, Vol.10 (12), p.1399
• Main Authors: Li, Xiwei, Tian, Shifeng, Ma, Changjun, Chen, Lihua, Qin, Jingwen, Wang, Nan, Lin, Liangjie, Liu, Ailian
• Format: Article
• Language: English
• Subjects: amide proton transfer-weighted imaging; Antigens; Bioengineering; Biopsy; Cancer; Cancer therapies; Cervical cancer; Correlation; Diagnosis; Diagnostic systems; diffusion kurtosis imaging; Effectiveness; Endometrial cancer; Endometrium; ErbB-2 protein; Gene amplification; Gene expression; Genetic aspects; Growth factors; Health aspects; Immunohistochemistry; Kinases; Kurtosis; Magnetic resonance imaging; Mapping; Medical imaging; Methods; Pathology; Patients; Radiation therapy; Statistical analysis; T2 mapping; Uterine cancer; Vagina
• ISSN: 2306-5354; 2306-5354
• DOI: 10.3390/bioengineering10121399

To assess the value of multimodal MRI, including amide proton transfer-weighted imaging (APT), diffusion kurtosis imaging (DKI), and T2 mapping sequences for estimating human epidermal growth factor receptor-2 (Her-2) expression in patients with endometrial cancer (EC). A total of 54 patients with EC who underwent multimodal pelvic MRI followed by biopsy were retrospectively selected and divided into the Her-2 positive (n = 24) and Her-2 negative (n = 30) groups. Her-2 expression was confirmed by immunohistochemistry (IHC). Two observers measured APT, mean kurtosis (MK), mean diffusivity (MD), and T2 values for EC lesions. The Her-2 (+) group showed higher APT values and lower MD and T2 values than the Her-2 (-) group (all < 0.05); there was no significant difference in MK values ( > 0.05). The area under the receiver operating characteristic curve (AUC) of APT, MD, T2, APT + T2, APT + MD, T2 + MD, and APT + MD + T2 models to identify the two groups of cases were 0.824, 0.695, 0.721, 0.824, 0.858, 0.782, and 0.860, respectively, and the diagnostic efficacy after combined APT + MD + T2 value was significantly higher than those of MD and T2 values individually ( = 0.018, 0.028); the diagnostic efficacy of the combination of APT + T2 values was significantly higher than that of T2 values separately ( = 0.028). Weak negative correlations were observed between APT and T2 values (r = -0.365, = 0.007), moderate negative correlations between APT and MD values (r = -0.560, < 0.001), and weak positive correlations between MD and T2 values (r = 0.336, = 0.013). The APT values were independent predictors for assessing Her-2 expression in EC patients. The APT, DKI, and T2 mapping sequences can be used to preoperatively assess the Her-2 expression in EC, which can contribute to more precise treatment for clinical preoperative.