The therapeutic applications of mesenchymal stromal cells from human perinatal tissues in autoimmune diseases

The autoimmune diseases are characterized by overactivation of immune cells, chronic inflammation, and immune response to self-antigens, leading to the damage and dysfunction of multiple organs. Patients still do not receive desired clinical outcomes while suffer from various adverse effects imparte...

Full description

Saved in:
Bibliographic Details
Published in:Stem cell research & therapy 2021-02, Vol.12 (1), p.103-103, Article 103
Main Authors: Yang, Chao, Wu, Mingjun, You, Min, Chen, Yu, Luo, Maowen, Chen, Qiang
Format: Article
Language:English
Subjects:
Amniotic fluid
Animal experimentation
Animal research
Antibodies
Antigens
Apoptosis
Autoantigens
Autoimmune diseases
Autophagy
B cells
Blood banks
Bone marrow
Cell adhesion & migration
Clinical trials
Coronaviruses
COVID-19
Cytokines
Disease
Growth factors
Health aspects
Immune diseases
Immune response
Immunomodulation
Inflammation
Lupus
Lymphocytes
Medical research
Medicine, Experimental
Mesenchymal stem cells
Mesenchymal stromal cell
Mesenchyme
Mitochondria
Multiple sclerosis
Perinatal tissues
Placenta
Placental membranes
Review
Rheumatoid arthritis
Stem cells
Stromal cells
Therapeutic applications
Transplantation
Umbilical cord
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The autoimmune diseases are characterized by overactivation of immune cells, chronic inflammation, and immune response to self-antigens, leading to the damage and dysfunction of multiple organs. Patients still do not receive desired clinical outcomes while suffer from various adverse effects imparted by current therapies. The therapeutic strategies based on mesenchymal stromal cell (MSC) transplantation have become the promising approach for the treatment of autoimmune diseases due to the immunomodulation property of MSCs. MSCs derived from perinatal tissues are collectively known as perinatal MSCs (PMSCs), which can be obtained via painless procedures from donors with lower risk of being contaminated by viruses than those MSCs from adult tissue sources. Therefore, PMSCs may be the ideal cell source for the treatment of autoimmune diseases. This article summarizes recent progress and possible mechanisms of PMSCs in treating autoimmune diseases in animal experiments and clinical studies. This review also presents existing challenges and proposes solutions, which may provide new hints on PMSC transplantation as a therapeutic strategy for the treatment of autoimmune diseases.
ISSN:1757-6512
1757-6512
DOI:10.1186/s13287-021-02158-3