The therapeutic applications of mesenchymal stromal cells from human perinatal tissues in autoimmune diseases

The autoimmune diseases are characterized by overactivation of immune cells, chronic inflammation, and immune response to self-antigens, leading to the damage and dysfunction of multiple organs. Patients still do not receive desired clinical outcomes while suffer from various adverse effects imparte...

Full description

Saved in:
Bibliographic Details
Published in:Stem cell research & therapy 2021-02, Vol.12 (1), p.103-103, Article 103
Main Authors: Yang, Chao, Wu, Mingjun, You, Min, Chen, Yu, Luo, Maowen, Chen, Qiang
Format: Article
Language:English
Subjects:
Amniotic fluid
Animal experimentation
Animal research
Antibodies
Antigens
Apoptosis
Autoantigens
Autoimmune diseases
Autophagy
B cells
Blood banks
Bone marrow
Cell adhesion & migration
Clinical trials
Coronaviruses
COVID-19
Cytokines
Disease
Growth factors
Health aspects
Immune diseases
Immune response
Immunomodulation
Inflammation
Lupus
Lymphocytes
Medical research
Medicine, Experimental
Mesenchymal stem cells
Mesenchymal stromal cell
Mesenchyme
Mitochondria
Multiple sclerosis
Perinatal tissues
Placenta
Placental membranes
Review
Rheumatoid arthritis
Stem cells
Stromal cells
Therapeutic applications
Transplantation
Umbilical cord
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c628t-86090b6be5ed6c6f98d0393911e5a914a07337ffcc00bd201c41e98207feb8c73
cites cdi_FETCH-LOGICAL-c628t-86090b6be5ed6c6f98d0393911e5a914a07337ffcc00bd201c41e98207feb8c73
container_end_page 103
container_issue 1
container_start_page 103
container_title Stem cell research & therapy
container_volume 12
creator Yang, Chao
Wu, Mingjun
You, Min
Chen, Yu
Luo, Maowen
Chen, Qiang
description The autoimmune diseases are characterized by overactivation of immune cells, chronic inflammation, and immune response to self-antigens, leading to the damage and dysfunction of multiple organs. Patients still do not receive desired clinical outcomes while suffer from various adverse effects imparted by current therapies. The therapeutic strategies based on mesenchymal stromal cell (MSC) transplantation have become the promising approach for the treatment of autoimmune diseases due to the immunomodulation property of MSCs. MSCs derived from perinatal tissues are collectively known as perinatal MSCs (PMSCs), which can be obtained via painless procedures from donors with lower risk of being contaminated by viruses than those MSCs from adult tissue sources. Therefore, PMSCs may be the ideal cell source for the treatment of autoimmune diseases. This article summarizes recent progress and possible mechanisms of PMSCs in treating autoimmune diseases in animal experiments and clinical studies. This review also presents existing challenges and proposes solutions, which may provide new hints on PMSC transplantation as a therapeutic strategy for the treatment of autoimmune diseases.
doi_str_mv 10.1186/s13287-021-02158-3
format article
fullrecord <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_c026aa19ef2645ada864aa2934a73d19</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A653691219</galeid><doaj_id>oai_doaj_org_article_c026aa19ef2645ada864aa2934a73d19</doaj_id><sourcerecordid>A653691219</sourcerecordid><originalsourceid>FETCH-LOGICAL-c628t-86090b6be5ed6c6f98d0393911e5a914a07337ffcc00bd201c41e98207feb8c73</originalsourceid><addsrcrecordid>eNptkl2L1DAUhoso7jLuH_BCCoLoRdd8tElzIyyLHwMLgq7X4Ux6Os3QNjVJF_ffm5lZ16nYUJImz3nT8_Jm2UtKLimtxftAOatlQRjdv1Vd8CfZOZWVLERF2dOT9Vl2EcKOpIdzQkT5PDvjvCppydh5Ntx2mMcOPUw4R2tymKbeGojWjSF3bT5gwNF09wP0eYje7WeDfR_yNn3k3TzAmE_o7QgxHUUbwowht2MOc3R2GOYR88YGhIDhRfashT7gxcO8yn58-nh7_aW4-fp5fX11UxjB6ljUgiiyERussBFGtKpuCFdcUYoVKFoCkZzLtjWGkE3DCDUlRVUzIlvc1EbyVbY-6jYOdnrydgB_rx1YfdhwfqvBp2571IYwAUAVtkyUFTRQixKAKV6C5A1VSevDUWuaNwM2BsfooV-ILk9G2-mtu9OyrpRKpq-ytw8C3v1M3kQ92LC3EEZ0c9CsrCWtZFnShL7-B9252Y_JqkSl9mslCftLbSE1YMfWpXvNXlRfiYoLRdnhvy__Q6XR4GCNG7G1aX9R8G5RkJiIv-IW5hD0-vu3JfvmhO0Q-tgF18-H2CxBdgSNdyF4bB-No0Tvg6yPQdYpxPoQZM1T0atTyx9L_sSW_wbSFOyZ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2491189702</pqid></control><display><type>article</type><title>The therapeutic applications of mesenchymal stromal cells from human perinatal tissues in autoimmune diseases</title><source>Open Access: PubMed Central</source><source>Publicly Available Content Database</source><source>Coronavirus Research Database</source><creator>Yang, Chao ; Wu, Mingjun ; You, Min ; Chen, Yu ; Luo, Maowen ; Chen, Qiang</creator><creatorcontrib>Yang, Chao ; Wu, Mingjun ; You, Min ; Chen, Yu ; Luo, Maowen ; Chen, Qiang</creatorcontrib><description>The autoimmune diseases are characterized by overactivation of immune cells, chronic inflammation, and immune response to self-antigens, leading to the damage and dysfunction of multiple organs. Patients still do not receive desired clinical outcomes while suffer from various adverse effects imparted by current therapies. The therapeutic strategies based on mesenchymal stromal cell (MSC) transplantation have become the promising approach for the treatment of autoimmune diseases due to the immunomodulation property of MSCs. MSCs derived from perinatal tissues are collectively known as perinatal MSCs (PMSCs), which can be obtained via painless procedures from donors with lower risk of being contaminated by viruses than those MSCs from adult tissue sources. Therefore, PMSCs may be the ideal cell source for the treatment of autoimmune diseases. This article summarizes recent progress and possible mechanisms of PMSCs in treating autoimmune diseases in animal experiments and clinical studies. This review also presents existing challenges and proposes solutions, which may provide new hints on PMSC transplantation as a therapeutic strategy for the treatment of autoimmune diseases.</description><identifier>ISSN: 1757-6512</identifier><identifier>EISSN: 1757-6512</identifier><identifier>DOI: 10.1186/s13287-021-02158-3</identifier><identifier>PMID: 33541422</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Amniotic fluid ; Animal experimentation ; Animal research ; Antibodies ; Antigens ; Apoptosis ; Autoantigens ; Autoimmune diseases ; Autophagy ; B cells ; Blood banks ; Bone marrow ; Cell adhesion &amp; migration ; Clinical trials ; Coronaviruses ; COVID-19 ; Cytokines ; Disease ; Growth factors ; Health aspects ; Immune diseases ; Immune response ; Immunomodulation ; Inflammation ; Lupus ; Lymphocytes ; Medical research ; Medicine, Experimental ; Mesenchymal stem cells ; Mesenchymal stromal cell ; Mesenchyme ; Mitochondria ; Multiple sclerosis ; Perinatal tissues ; Placenta ; Placental membranes ; Review ; Rheumatoid arthritis ; Stem cells ; Stromal cells ; Therapeutic applications ; Transplantation ; Umbilical cord</subject><ispartof>Stem cell research &amp; therapy, 2021-02, Vol.12 (1), p.103-103, Article 103</ispartof><rights>COPYRIGHT 2021 BioMed Central Ltd.</rights><rights>2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c628t-86090b6be5ed6c6f98d0393911e5a914a07337ffcc00bd201c41e98207feb8c73</citedby><cites>FETCH-LOGICAL-c628t-86090b6be5ed6c6f98d0393911e5a914a07337ffcc00bd201c41e98207feb8c73</cites><orcidid>0000-0001-6351-2327</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859900/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2491189702?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,38516,43895,44590,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33541422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Chao</creatorcontrib><creatorcontrib>Wu, Mingjun</creatorcontrib><creatorcontrib>You, Min</creatorcontrib><creatorcontrib>Chen, Yu</creatorcontrib><creatorcontrib>Luo, Maowen</creatorcontrib><creatorcontrib>Chen, Qiang</creatorcontrib><title>The therapeutic applications of mesenchymal stromal cells from human perinatal tissues in autoimmune diseases</title><title>Stem cell research &amp; therapy</title><addtitle>Stem Cell Res Ther</addtitle><description>The autoimmune diseases are characterized by overactivation of immune cells, chronic inflammation, and immune response to self-antigens, leading to the damage and dysfunction of multiple organs. Patients still do not receive desired clinical outcomes while suffer from various adverse effects imparted by current therapies. The therapeutic strategies based on mesenchymal stromal cell (MSC) transplantation have become the promising approach for the treatment of autoimmune diseases due to the immunomodulation property of MSCs. MSCs derived from perinatal tissues are collectively known as perinatal MSCs (PMSCs), which can be obtained via painless procedures from donors with lower risk of being contaminated by viruses than those MSCs from adult tissue sources. Therefore, PMSCs may be the ideal cell source for the treatment of autoimmune diseases. This article summarizes recent progress and possible mechanisms of PMSCs in treating autoimmune diseases in animal experiments and clinical studies. This review also presents existing challenges and proposes solutions, which may provide new hints on PMSC transplantation as a therapeutic strategy for the treatment of autoimmune diseases.</description><subject>Amniotic fluid</subject><subject>Animal experimentation</subject><subject>Animal research</subject><subject>Antibodies</subject><subject>Antigens</subject><subject>Apoptosis</subject><subject>Autoantigens</subject><subject>Autoimmune diseases</subject><subject>Autophagy</subject><subject>B cells</subject><subject>Blood banks</subject><subject>Bone marrow</subject><subject>Cell adhesion &amp; migration</subject><subject>Clinical trials</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Cytokines</subject><subject>Disease</subject><subject>Growth factors</subject><subject>Health aspects</subject><subject>Immune diseases</subject><subject>Immune response</subject><subject>Immunomodulation</subject><subject>Inflammation</subject><subject>Lupus</subject><subject>Lymphocytes</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Mesenchymal stem cells</subject><subject>Mesenchymal stromal cell</subject><subject>Mesenchyme</subject><subject>Mitochondria</subject><subject>Multiple sclerosis</subject><subject>Perinatal tissues</subject><subject>Placenta</subject><subject>Placental membranes</subject><subject>Review</subject><subject>Rheumatoid arthritis</subject><subject>Stem cells</subject><subject>Stromal cells</subject><subject>Therapeutic applications</subject><subject>Transplantation</subject><subject>Umbilical cord</subject><issn>1757-6512</issn><issn>1757-6512</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>COVID</sourceid><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkl2L1DAUhoso7jLuH_BCCoLoRdd8tElzIyyLHwMLgq7X4Ux6Os3QNjVJF_ffm5lZ16nYUJImz3nT8_Jm2UtKLimtxftAOatlQRjdv1Vd8CfZOZWVLERF2dOT9Vl2EcKOpIdzQkT5PDvjvCppydh5Ntx2mMcOPUw4R2tymKbeGojWjSF3bT5gwNF09wP0eYje7WeDfR_yNn3k3TzAmE_o7QgxHUUbwowht2MOc3R2GOYR88YGhIDhRfashT7gxcO8yn58-nh7_aW4-fp5fX11UxjB6ljUgiiyERussBFGtKpuCFdcUYoVKFoCkZzLtjWGkE3DCDUlRVUzIlvc1EbyVbY-6jYOdnrydgB_rx1YfdhwfqvBp2571IYwAUAVtkyUFTRQixKAKV6C5A1VSevDUWuaNwM2BsfooV-ILk9G2-mtu9OyrpRKpq-ytw8C3v1M3kQ92LC3EEZ0c9CsrCWtZFnShL7-B9252Y_JqkSl9mslCftLbSE1YMfWpXvNXlRfiYoLRdnhvy__Q6XR4GCNG7G1aX9R8G5RkJiIv-IW5hD0-vu3JfvmhO0Q-tgF18-H2CxBdgSNdyF4bB-No0Tvg6yPQdYpxPoQZM1T0atTyx9L_sSW_wbSFOyZ</recordid><startdate>20210204</startdate><enddate>20210204</enddate><creator>Yang, Chao</creator><creator>Wu, Mingjun</creator><creator>You, Min</creator><creator>Chen, Yu</creator><creator>Luo, Maowen</creator><creator>Chen, Qiang</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-6351-2327</orcidid></search><sort><creationdate>20210204</creationdate><title>The therapeutic applications of mesenchymal stromal cells from human perinatal tissues in autoimmune diseases</title><author>Yang, Chao ; Wu, Mingjun ; You, Min ; Chen, Yu ; Luo, Maowen ; Chen, Qiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c628t-86090b6be5ed6c6f98d0393911e5a914a07337ffcc00bd201c41e98207feb8c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Amniotic fluid</topic><topic>Animal experimentation</topic><topic>Animal research</topic><topic>Antibodies</topic><topic>Antigens</topic><topic>Apoptosis</topic><topic>Autoantigens</topic><topic>Autoimmune diseases</topic><topic>Autophagy</topic><topic>B cells</topic><topic>Blood banks</topic><topic>Bone marrow</topic><topic>Cell adhesion &amp; migration</topic><topic>Clinical trials</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Cytokines</topic><topic>Disease</topic><topic>Growth factors</topic><topic>Health aspects</topic><topic>Immune diseases</topic><topic>Immune response</topic><topic>Immunomodulation</topic><topic>Inflammation</topic><topic>Lupus</topic><topic>Lymphocytes</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Mesenchymal stem cells</topic><topic>Mesenchymal stromal cell</topic><topic>Mesenchyme</topic><topic>Mitochondria</topic><topic>Multiple sclerosis</topic><topic>Perinatal tissues</topic><topic>Placenta</topic><topic>Placental membranes</topic><topic>Review</topic><topic>Rheumatoid arthritis</topic><topic>Stem cells</topic><topic>Stromal cells</topic><topic>Therapeutic applications</topic><topic>Transplantation</topic><topic>Umbilical cord</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Chao</creatorcontrib><creatorcontrib>Wu, Mingjun</creatorcontrib><creatorcontrib>You, Min</creatorcontrib><creatorcontrib>Chen, Yu</creatorcontrib><creatorcontrib>Luo, Maowen</creatorcontrib><creatorcontrib>Chen, Qiang</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest_Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Biological Science Journals</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Stem cell research &amp; therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Chao</au><au>Wu, Mingjun</au><au>You, Min</au><au>Chen, Yu</au><au>Luo, Maowen</au><au>Chen, Qiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The therapeutic applications of mesenchymal stromal cells from human perinatal tissues in autoimmune diseases</atitle><jtitle>Stem cell research &amp; therapy</jtitle><addtitle>Stem Cell Res Ther</addtitle><date>2021-02-04</date><risdate>2021</risdate><volume>12</volume><issue>1</issue><spage>103</spage><epage>103</epage><pages>103-103</pages><artnum>103</artnum><issn>1757-6512</issn><eissn>1757-6512</eissn><abstract>The autoimmune diseases are characterized by overactivation of immune cells, chronic inflammation, and immune response to self-antigens, leading to the damage and dysfunction of multiple organs. Patients still do not receive desired clinical outcomes while suffer from various adverse effects imparted by current therapies. The therapeutic strategies based on mesenchymal stromal cell (MSC) transplantation have become the promising approach for the treatment of autoimmune diseases due to the immunomodulation property of MSCs. MSCs derived from perinatal tissues are collectively known as perinatal MSCs (PMSCs), which can be obtained via painless procedures from donors with lower risk of being contaminated by viruses than those MSCs from adult tissue sources. Therefore, PMSCs may be the ideal cell source for the treatment of autoimmune diseases. This article summarizes recent progress and possible mechanisms of PMSCs in treating autoimmune diseases in animal experiments and clinical studies. This review also presents existing challenges and proposes solutions, which may provide new hints on PMSC transplantation as a therapeutic strategy for the treatment of autoimmune diseases.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>33541422</pmid><doi>10.1186/s13287-021-02158-3</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-6351-2327</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1757-6512
ispartof Stem cell research & therapy, 2021-02, Vol.12 (1), p.103-103, Article 103
issn 1757-6512
1757-6512
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_c026aa19ef2645ada864aa2934a73d19
source Open Access: PubMed Central; Publicly Available Content Database; Coronavirus Research Database
subjects Amniotic fluid
Animal experimentation
Animal research
Antibodies
Antigens
Apoptosis
Autoantigens
Autoimmune diseases
Autophagy
B cells
Blood banks
Bone marrow
Cell adhesion & migration
Clinical trials
Coronaviruses
COVID-19
Cytokines
Disease
Growth factors
Health aspects
Immune diseases
Immune response
Immunomodulation
Inflammation
Lupus
Lymphocytes
Medical research
Medicine, Experimental
Mesenchymal stem cells
Mesenchymal stromal cell
Mesenchyme
Mitochondria
Multiple sclerosis
Perinatal tissues
Placenta
Placental membranes
Review
Rheumatoid arthritis
Stem cells
Stromal cells
Therapeutic applications
Transplantation
Umbilical cord
title The therapeutic applications of mesenchymal stromal cells from human perinatal tissues in autoimmune diseases
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T03%3A15%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20therapeutic%20applications%20of%20mesenchymal%20stromal%20cells%20from%20human%20perinatal%20tissues%20in%20autoimmune%20diseases&rft.jtitle=Stem%20cell%20research%20&%20therapy&rft.au=Yang,%20Chao&rft.date=2021-02-04&rft.volume=12&rft.issue=1&rft.spage=103&rft.epage=103&rft.pages=103-103&rft.artnum=103&rft.issn=1757-6512&rft.eissn=1757-6512&rft_id=info:doi/10.1186/s13287-021-02158-3&rft_dat=%3Cgale_doaj_%3EA653691219%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c628t-86090b6be5ed6c6f98d0393911e5a914a07337ffcc00bd201c41e98207feb8c73%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2491189702&rft_id=info:pmid/33541422&rft_galeid=A653691219&rfr_iscdi=true