A data-driven methodology towards evaluating the potential of drug repurposing hypotheses

• Published in: Computational and structural biotechnology journal 2021-01, Vol.19, p.4559-4573
• Main Authors: Prieto Santamaría, Lucía, Ugarte Carro, Esther, Díaz Uzquiano, Marina, Menasalvas Ruiz, Ernestina, Pérez Gallardo, Yuliana, Rodríguez-González, Alejandro
• Format: Article
• Language: English
• Subjects: Data integration; Disease understanding; DISNET knowledge base; Drug repositioning; Drug repurposing; Drug-disease validation
• ISSN: 2001-0370; 2001-0370
• DOI: 10.1016/j.csbj.2021.08.003

[Display omitted] Drug repurposing has become a widely used strategy to accelerate the process of finding treatments. While classical de novo drug development involves high costs, risks, and time-consuming paths, drug repurposing allows to reuse already-existing and approved drugs for new indications. Numerous research has been carried out in this field, both in vitro and in silico. Computational drug repurposing methods make use of modern heterogeneous biomedical data to identify and prioritize new indications for old drugs. In the current paper, we present a new complete methodology to evaluate new potentially repurposable drugs based on disease-gene and disease-phenotype associations, identifying significant differences between repurposing and non-repurposing data. We have collected a set of known successful drug repurposing case studies from the literature and we have analysed their dissimilarities with other biomedical data not necessarily participating in repurposing processes. The information used has been obtained from the DISNET platform. We have performed three analyses (at the genetical, phenotypical, and categorization levels), to conclude that there is a statistically significant difference between actual repurposing-related information and non-repurposing data. The insights obtained could be relevant when suggesting new potential drug repurposing hypotheses.