Risk factors for symptomatic vascular events in giant cell arteritis: a study of 254 patients with large-vessel imaging at diagnosis

Aims: To identify factors associated with vascular events in patients with giant cell arteritis (GCA). Methods: We performed a retrospective study of GCA patients diagnosed over a 20-year-period, who all underwent vascular imaging evaluation at diagnosis. Symptomatic vascular events were defined as...

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Published in:Therapeutic advances in musculoskeletal disease 2021, Vol.13, p.1759720X211006967-1759720X211006967
Main Authors: de Mornac, Donatienne, Agard, Christian, Hardouin, Jean-Benoit, Hamidou, Mohamed, Connault, Jérôme, Masseau, Agathe, Espitia-Thibault, Alexandra, Artifoni, Mathieu, Ngohou, Chan, Perrin, François, Graveleau, Julie, Durant, Cécile, Pottier, Pierre, Néel, Antoine, Espitia, Olivier
Format: Article
Language:English
Subjects:
Coronary vessels
Diabetes
Hypertension
Ischemia
Medical diagnosis
Original Research
Risk factors
Stroke
Surgery
Vein & artery diseases
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Summary:Aims: To identify factors associated with vascular events in patients with giant cell arteritis (GCA). Methods: We performed a retrospective study of GCA patients diagnosed over a 20-year-period, who all underwent vascular imaging evaluation at diagnosis. Symptomatic vascular events were defined as the occurrence of any aortic event (aortic dissection or symptomatic aortic aneurysm), stroke, myocardial infarction, limb or mesenteric ischemia and de novo lower limbs arteritis stage 3 or 4. Patients with symptomatic vascular event (VE+) and without were compared, and risk factors were identified in a multivariable analysis. Results: Thirty-nine (15.4%) of the 254 included patients experienced at least one symptomatic vascular event during follow-up, with a median time of 21.5 months. Arterial hypertension, diabetes, lower limbs arteritis or vascular complication at diagnosis were more frequent in VE+ patients (p 
ISSN:1759-720X
1759-7218
DOI:10.1177/1759720X211006967