Prevalence and predicting factors of Group A beta-hemolytic Streptococcus carrier state in primary schoolchildren

Introduction : Transmission of Group A Streptococcus from asymptomatic children to their surrounding carries a risk of acute rheumatic fever in susceptible people. Aim and Objectives : We aimed to investigate the prevalence and predictors of GAS carrier state and evaluate the antibiotic sensitivity...

Full description

Saved in:
Bibliographic Details
Published in:Annals of pediatric cardiology 2021-10, Vol.14 (4), p.471-475
Main Authors: Rahmadhany, Anisa, Advani, Najib, Djer, Mulyadi, Handryastuti, Setyo, Safari, Dodi
Format: Article
Language:English
Subjects:
acute rheumatic fever
antibiotic sensitivity testing
Asymptomatic
Elementary school students
Elementary schools
group a streptococcus
India
Indonesia
Original
Penicillin
Penicillin G
Rheumatic fever
Streptococcus infections
Tetracycline
Tetracyclines
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction : Transmission of Group A Streptococcus from asymptomatic children to their surrounding carries a risk of acute rheumatic fever in susceptible people. Aim and Objectives : We aimed to investigate the prevalence and predictors of GAS carrier state and evaluate the antibiotic sensitivity pattern of GAS in Jakarta, Indonesia. Material and Methods : We enrolled 201 asymptomatic schoolchildren (6-12 years) using stratified random sampling from a primary school in Jakarta. None of the children had a history of rheumatic fever or rheumatic heart disease. All participants underwent physical examination, and laboratory tests include complete blood count, erythrocyte sedimentation rate, C-reactive protein, antistreptolysin O titer, and throat swab culture. Results : The prevalence of GAS carrier was 13.9% (95% confidence interval: 9.2%-18.6%) in our study. On multivariate analysis, tonsillar enlargement was found to be the only predicting factor of GAS carrier (P = 0.03). GAS was sensitive to penicillin G, erythromycin, vancomycin, clindamycin, chloramphenicol, azithromycin, and tetracycline in 100%, 89%, 86%, 75%, 68%, 68%, and 32% of patients, respectively. Conclusion : The GAS carrier state is common among school-age children affecting approximately 13.9% children. Tonsillar enlargement is a significant finding predictive of GAS carrier state. All isolates are still sensitive to penicillin and mostly sensitive to erythromycin but are increasingly resistant to tetracycline.
ISSN:0974-2069
0974-5149
DOI:10.4103/apc.apc_280_20