Navigating the ventricles: Novel insights into the pathogenesis of hydrocephalus

Congenital hydrocephalus occurs in one in 500–1000 babies born in the United States and acquired hydrocephalus may occur as the consequence of stroke, intraventricular and subarachnoid hemorrhage, traumatic brain injuries, brain tumors, craniectomy or may be idiopathic, as in the case of normal pres...

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Bibliographic Details
Published in:EBioMedicine 2022-04, Vol.78, p.103931-103931, Article 103931
Main Authors: Bramall, Alexa N., Anton, E.S., Kahle, Kristopher T., Fecci, Peter E.
Format: Article
Language:English
Subjects:
Choroid plexus
Ependymal cells
Glymphatic system
Heart Ventricles
Humans
Hydrocephalus
Hydrocephalus - etiology
Hydrocephalus - surgery
Infant
Quality of Life
Review
Subarachnoid Hemorrhage
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Summary:Congenital hydrocephalus occurs in one in 500–1000 babies born in the United States and acquired hydrocephalus may occur as the consequence of stroke, intraventricular and subarachnoid hemorrhage, traumatic brain injuries, brain tumors, craniectomy or may be idiopathic, as in the case of normal pressure hydrocephalus. Irrespective of its prevalence and significant impact on quality of life, neurosurgeons still rely on invasive cerebrospinal fluid shunt systems for the treatment of hydrocephalus that are exceptionally prone to failure and/or infection. Further understanding of this process at a molecular level, therefore, may have profound implications for improving treatment and quality of life for millions of individuals worldwide. The purpose of this article is to review the current research landscape on hydrocephalus with a focus on recent advances in our understanding of cerebrospinal fluid pathways from an evolutionary, genetics and molecular perspective.
ISSN:2352-3964
2352-3964
DOI:10.1016/j.ebiom.2022.103931