Heparan sulfate proteoglycans and heparanases in Alzheimer's disease: current outlook and potential therapeutic targets

[...]previous data have pointed out that the HS-Aβ interaction contributes to every stage of pathogenesis in AD, including production, clearance, accumulation, aggregation, and toxicity of Aβ (van Horssen et al., 2002; Cui et al., 2013). [...]work over the last decade indicates that Taupathology can...

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Bibliographic Details
Published in:Neural regeneration research 2017-06, Vol.12 (6), p.914-915
Main Authors: Lorente-Gea, Laura, García, Beatriz, Martín, Carla, Quirós, Luis M, Fernández-Vega, Iván
Format: Article
Language:English
Subjects:
Alzheimer's disease
Brain research
Enzymes
Health aspects
Heparan sulfate
Hypotheses
Neurotoxicity
Older people
Pathogenesis
Properties
Proteins
Proteoglycans
Risk factors
Statistics
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Summary:[...]previous data have pointed out that the HS-Aβ interaction contributes to every stage of pathogenesis in AD, including production, clearance, accumulation, aggregation, and toxicity of Aβ (van Horssen et al., 2002; Cui et al., 2013). [...]work over the last decade indicates that Taupathology can propagate between cells in a prion-like manner mediated by HSPGs (Holmes and Diamond, 2014). [...]recent studies have shown that overexpression of HPSE lowers the amyloid burden in transgenic mouse models of AD (Jendresen et al., 2015). [...]blocking at different levels HPSE2 using target drugs should increase HPSE activity facilitating NPs degradation and thus decreasing neurotoxicity; and reducing prion-like propagation of hyperphosphorilated Tau in AD ([Figure 1]A and [Figure 1]B).
ISSN:1673-5374
1876-7958
DOI:10.4103/1673-5374.208571