Novel therapy in Acute myeloid leukemia (AML): moving toward targeted approaches

Acute myeloid leukemia (AML) is a heterogenous and complex disease characterized by rapid cellular proliferation, an aggressive clinical course, and generally high mortality. While progress has been made in the understanding of the genetic and molecular biology of the disease, the standard of care f...

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Bibliographic Details
Published in:Therapeutic Advances in Hematology 2019, Vol.10, p.2040620719860645-2040620719860645
Main Authors: Winer, Eric S., Stone, Richard M.
Format: Article
Language:English
Subjects:
Cell cycle
Clinical trials
Immunotherapy
Leukemia
Review
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Summary:Acute myeloid leukemia (AML) is a heterogenous and complex disease characterized by rapid cellular proliferation, an aggressive clinical course, and generally high mortality. While progress has been made in the understanding of the genetic and molecular biology of the disease, the standard of care for patients had only changed minimally over the past 40 years. Recently, rapid movement of potentially useful agents from bench to bedside has translated into new therapies either recently approved or in clinical trials. These therapies include improved chemotherapies, mutationally targeted inhibitors, pro-apoptotic agents, microenvironment targeting molecules, cell cycle checkpoint inhibitors, and epigenetic regulators. Furthermore, advances in immunotherapy employ monoclonal and bispecific antibodies, chimeric antigen receptor (CAR) T cells, checkpoint inhibitors, and vaccines provide an alternative pathway for AML treatment. In this review, we discuss the recent results of completed or ongoing clinical trials with these novel therapeutic agents in AML.
ISSN:2040-6207
2040-6215
DOI:10.1177/2040620719860645