Single‐cell landscape of malignant ascites from patients with metastatic colorectal cancer

(D) Differential gene expression reveals significantly up-regulated and down-regulated genes in 11 cell types between PD and SD patients. (G) Dot plots show communication probability of the interactions between cell populations in pmCRC ascites (The dot size is proportional to the contribution score...

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Published in:Cancer communications (London, England) England), 2024-07, Vol.44 (7), p.713-717
Main Authors: Zhou, Haiyang, Yin, Jiahui, Wang, Anqi, Yin, Xiaomao, Jin, Taojun, Xu, Kai, Zhu, Lin, Wang, Jiexuan, Wang, Wenqiang, Zhang, Wei, Li, Xinxiang, Hu, Zhiqian, Li, Xinxing
Format: Article
Language:English
Subjects:
Antigens
Ascites
Cancer therapies
Cell death
Chemokines
Colorectal cancer
Extracellular matrix
Fibroblasts
Gene expression
Genomes
Hepatitis
Immunoglobulins
Letter to the Journal
Leukocytes
Ligands
Lymphocytes
Medical prognosis
Metastasis
Patients
Tumors
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container_issue 7
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container_title Cancer communications (London, England)
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creator Zhou, Haiyang
Yin, Jiahui
Wang, Anqi
Yin, Xiaomao
Jin, Taojun
Xu, Kai
Zhu, Lin
Wang, Jiexuan
Wang, Wenqiang
Zhang, Wei
Li, Xinxiang
Hu, Zhiqian
Li, Xinxing
description (D) Differential gene expression reveals significantly up-regulated and down-regulated genes in 11 cell types between PD and SD patients. (G) Dot plots show communication probability of the interactions between cell populations in pmCRC ascites (The dot size is proportional to the contribution score computed from pattern recognition analysis.). Differentially expressed genes and gene ontology (GO) analyses showed that the “cell-cell adhesion”, “inflammatory response”, and “cytokine production” were differentially enriched between primary tumors and ascites (Supplementary Figure S1D), which implied that the liquid state of ascites changed the functions of the fibroblast populations. Because the expression pattern of the “M2” marker gene CD163 perfectly coincided with that of LAIR1 in all sub-clusters (Figure 1M), we postulated that the immunosuppressive function of tumor-associated macrophages (TAMs) might be exerted via LAIR1.
doi_str_mv 10.1002/cac2.12541
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subjects Antigens
Ascites
Cancer therapies
Cell death
Chemokines
Colorectal cancer
Extracellular matrix
Fibroblasts
Gene expression
Genomes
Hepatitis
Immunoglobulins
Letter to the Journal
Leukocytes
Ligands
Lymphocytes
Medical prognosis
Metastasis
Patients
Tumors
title Single‐cell landscape of malignant ascites from patients with metastatic colorectal cancer
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