A three-dimensional morpho-volumetric similarity study of Down syndrome keratopathy vs. keratoconus

To compare and contrast morpho-volumetric features between Down syndrome (DS) cornea and non-DS keratoconic cornea by three-dimensional (3D) modelling. Forty-three subjects (43 eyes) with DS and 99 patients matching their age and sex (99 eyes) with keratoconus (KC) were included in this single-cente...

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Bibliographic Details
Published in:Eye and vision (Novato, Calif.) Calif.), 2023-01, Vol.10 (1), p.4-7, Article 4
Main Authors: Toprak, Ibrahim, Cavas, Francisco, Velázquez, José S, Alio Del Barrio, Jorge L, Alio, Jorge L
Format: Article
Language:English
Subjects:
Analysis
Corneal model
Corneal structure
Down syndrome
Keratoconus
Keratopathy
Medical research
Medicine, Experimental
Morphogeometry
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Summary:To compare and contrast morpho-volumetric features between Down syndrome (DS) cornea and non-DS keratoconic cornea by three-dimensional (3D) modelling. Forty-three subjects (43 eyes) with DS and 99 patients matching their age and sex (99 eyes) with keratoconus (KC) were included in this single-center cross-sectional study. Main outcome measures were high-order aberrations (HOA), central corneal thickness (CCT), spherical equivalent refraction, and morpho-volumetric parameters established using a 3D corneal model, such as deviation of anterior and posterior corneal apices (D /D ) and minimum thickness points (D /D ) from corneal vertex, areas of the anterior and posterior surfaces (A /A ), sagittal area passing through the anterior and posterior corneal apices (A /A ) and minimum thickness point (A ) and corneal volume of the complete cornea (V ). Age, gender, spherical equivalent refraction, CCT and V were similar between the net on-DS KC and DS groups (P > 0.05), while non-DS KC group had higher HOA than the DS group (P 
ISSN:2326-0254
2326-0254
DOI:10.1186/s40662-022-00315-0