Strong Antimicrobial Activity of Highly Stable Nanocomposite Containing AgNPs Based on Water-Soluble Triazole-Sulfonate Copolymer

A new hydrophilic polymeric nanocomposite containing AgNPs was synthesized by chemical reduction of metal ions in an aqueous medium in the presence of the copolymer. A new water-soluble copolymer of 1-vinyl-1,2,4-triazole and vinylsulfonic acid sodium salt (poly(VT-co-Na-VSA)) was obtained by free-r...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceutics 2022-01, Vol.14 (1), p.206
Main Authors: Pozdnyakov, Alexander, Emel'yanov, Artem, Ivanova, Anastasiya, Kuznetsova, Nadezhda, Semenova, Tat'yana, Bolgova, Yuliya, Korzhova, Svetlana, Trofimova, Olga, Fadeeva, Tat'yana, Prozorova, Galina
Format: Article
Language:English
Subjects:
1-vinyl-1,2,4-triazole
Acids
antimicrobial activity
Antimicrobial agents
Biological activity
Cellulose
Fourier transforms
hydrophilic nanocomposite
Molecular weight
Nanocomposites
Nanoparticles
Salt
Silver
silver nanoparticles
Sodium
vinylsulfonic acid sodium salt
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new hydrophilic polymeric nanocomposite containing AgNPs was synthesized by chemical reduction of metal ions in an aqueous medium in the presence of the copolymer. A new water-soluble copolymer of 1-vinyl-1,2,4-triazole and vinylsulfonic acid sodium salt (poly(VT-co-Na-VSA)) was obtained by free-radical copolymerization and was used as a stabilizing precursor agent. The structural, dimensional, and morphological properties of the nanocomposite were studied by UV-Vis, FTIR, X-ray diffraction, atomic absorption, transmission and scanning electron microscopy, dynamic and electrophoretic light scattering, gel permeation chromatography, thermogravimetric analysis, and differential scanning calorimetry. Hydrodynamic diameter of macroclubs for the copolymer was 171 nm, and for the nanocomposite it was 694 nm. Zeta potential for the copolymer was -63.8 mV, and for the nanocomposite it was -70.4 mV. The nanocomposite had strong antimicrobial activity towards Gram-negative and Gram-positive microorganisms: MIC and MBC values were in the range of 0.25-4.0 and 0.5-8.0 μg/mL, respectively.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics14010206