Madelung's disease associated with polyneuropathy and symptomatic hypokalemia

Madelung's disease (multiple symmetric lipomatosis) is a rare disease characterized by abnormal diffuse lipomatosis in proximal upper limbs and neck. Previous reports have shown that this disease is associated with alcoholism, polyneuropathy, mitochondrial disease, and glucose intolerance. Here...

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Bibliographic Details
Published in:Journal of the Formosan Medical Association 2013-05, Vol.112 (5), p.283-286
Main Authors: Chan, Hoi-Fong, Sun, Yu, Lin, Cheng-Huai, Chen, Rong-Chi
Format: Article
Language:English
Subjects:
Humans
Hypokalemia - etiology
hypokalemic periodic paralysis
Internal Medicine
Launois–Bensaude syndrome
Lipomatosis, Multiple Symmetrical - complications
Lipomatosis, Multiple Symmetrical - therapy
Madelung's disease
Male
Middle Aged
multiple symmetric lipomatosis
Phenotype
Polyneuropathies - etiology
polyneuropathy
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Summary:Madelung's disease (multiple symmetric lipomatosis) is a rare disease characterized by abnormal diffuse lipomatosis in proximal upper limbs and neck. Previous reports have shown that this disease is associated with alcoholism, polyneuropathy, mitochondrial disease, and glucose intolerance. Here, we describe a 46-year-old man having Madelung's disease associated with polyneuropathy and symptomatic hypokalemia. He presented with insidious-onset weakness and numbness in lower limbs for 7 years and recent deterioration of symptoms. Proximal weakness improved with potassium supplement. Our observation may extend the phenotype of Madelung's disease to hypokalemic periodic paralysis.
ISSN:0929-6646
DOI:10.1016/j.jfma.2012.07.019