Functional imaging of immune cell subpopulations in the tumor microenvironment: clinical implications

In cancer, peripheral blood immune monitoring remains an ineffective strategy for assessing immunotherapeutic response, since it does not interrogate immune cell function within the immunosuppressive tumor microenvironment (TME). Tumor immune cells can infiltrate at a high frequency without imposing...

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Bibliographic Details
Published in:The Journal of clinical investigation 2022-08, Vol.132 (16), p.1-1
Main Author: Heimberger, Amy B
Format: Article
Language:English
Subjects:
Antigens
Antitumor activity
Biomedical research
Brain cancer
Cancer cells
Cancer therapies
Clinical trials
Colorectal cancer
Editor’s Note
Evaluation
Health aspects
Immune response
Immunotherapy
Lymphocytes
Patients
Peripheral blood
PET imaging
Physiological aspects
Proteases
T cells
Tumor microenvironment
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Summary:In cancer, peripheral blood immune monitoring remains an ineffective strategy for assessing immunotherapeutic response, since it does not interrogate immune cell function within the immunosuppressive tumor microenvironment (TME). Tumor immune cells can infiltrate at a high frequency without imposing antitumor activity. Thus, window-of-opportunity clinical trials are an ongoing strategy to characterize the immune cells in the TME. Longitudinal assessments based on the analysis of multiple patient tumor samples collected at several time points would help precisely define a patient's response to immunotherapy, but in many instances these are unavailable. Furthermore, immune reactivity in the TME can be markedly heterogenous, and limited sampling of the TME can yield misleading results.
ISSN:1558-8238
0021-9738
1558-8238
DOI:10.1172/JCI162962