Metastatic organotropism: a brief overview

Organotropism has been known since 1889, yet this vital component of metastasis has predominantly stayed elusive. This mini-review gives an overview of the current understanding of the underlying mechanisms of organotropism and metastases development by focusing on the formation of the pre-metastati...

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Bibliographic Details
Published in:Frontiers in oncology 2024, Vol.14, p.1358786-1358786
Main Authors: Carrolo, Margarida, Miranda, João A I, Vilhais, Guilherme, Quintela, António, Sousa, Mário Fontes E, Costa, Diogo Alpuim, Pinto, Francisco R
Format: Article
Language:English
Subjects:
brain metastasis
immune response to metastasis
metastasis
Oncology
organotropism
pre-metastatic niche
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Summary:Organotropism has been known since 1889, yet this vital component of metastasis has predominantly stayed elusive. This mini-review gives an overview of the current understanding of the underlying mechanisms of organotropism and metastases development by focusing on the formation of the pre-metastatic niche, immune defenses against metastases, and genomic alterations associated with organotropism. The particular case of brain metastases is also addressed, as well as the impact of organotropism in cancer therapy. The limited comprehension of the factors behind organotropism underscores the necessity for efficient strategies and treatments to manage metastases.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2024.1358786