HHV8-Negative Primary Effusion Lymphoma of B-Cell Lineage : Two Cases and a Comprehensive Review of the Literature

Primary effusion lymphoma (PEL) is a rare extranodal lymphoma that typically presents in a body cavity in the absence of a detectable tumor mass and that occurs predominantly in immunosuppressed individuals. The neoplastic lymphoid cells are frequently infected with human herpes virus 8 (HHV8), also...

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Bibliographic Details
Published in:Case reports in oncological medicine 2013-01, Vol.2013 (2013), p.1-12
Main Authors: Hochberg, Ephraim P., Jha, Smita, Saini, Neeraj, Sohani, Aliyah R., Grohs, Heinz K., Linden, Erica A.
Format: Article
Language:English
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Case Report
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Summary:Primary effusion lymphoma (PEL) is a rare extranodal lymphoma that typically presents in a body cavity in the absence of a detectable tumor mass and that occurs predominantly in immunosuppressed individuals. The neoplastic lymphoid cells are frequently infected with human herpes virus 8 (HHV8), also known as Kaposi sarcoma herpes virus (KSHV). We describe two HIV-negative patients who presented with primary effusion lymphoma of B-cell lineage involving the pleural cavity, but whose tumor cells lacked infection by HHV8. We review the English language literature of HHV8-negative PEL of B-cell lineage and compare these lymphomas to HHV8-associated PEL with regard to clinical and pathological characteristics, therapy, and outcome.
ISSN:2090-6706
2090-6714
DOI:10.1155/2013/292301