Enhanced production of Th1- and Th2-type antibodies and induction of regulatory T cells in mice by oral administration of Cyclopia extracts with similar phenolic composition to honeybush herbal tea

[Display omitted] •Oral ingestion of Cyclopia extracts resulted in immunomodulatory activity in mice.•Cyclopia extracts enhanced systemic humoral immune responses.•Cyclopia extracts induced regulatory T cells.•Effective mouse dose translated to HED of ca 300 mL herbal tea/day. Immune-regulating acti...

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Bibliographic Details
Published in:Journal of functional foods 2020-01, Vol.64, p.103704, Article 103704
Main Authors: Yoshida, Tadashi, Malherbe, Christiaan J., Okon, Kazunobu, Miura, Yutaka, Hattori, Makoto, Matsuda, Hiroshi, Muller, Christo J.F., Joubert, Elizabeth
Format: Article
Language:English
Subjects:
Antibody
Cytokine
Honeybush
Regulatory T cell
Th1 and Th2
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Summary:[Display omitted] •Oral ingestion of Cyclopia extracts resulted in immunomodulatory activity in mice.•Cyclopia extracts enhanced systemic humoral immune responses.•Cyclopia extracts induced regulatory T cells.•Effective mouse dose translated to HED of ca 300 mL herbal tea/day. Immune-regulating activity of Cyclopia subternata and C. genistoides extracts (honeybush tea) in vitro, using a murine cell culture, merited investigation of their immune-regulating functions in vivo. Oral administration of the extracts and ovalbumin (OVA) to OVA specific-T cell receptor transgenic mice (DO11.10) significantly (P 
ISSN:1756-4646
2214-9414
DOI:10.1016/j.jff.2019.103704