Effects of inhaled hypertonic (7%) saline on lung function test in preschool children with cystic fibrosis: results of a crossover, randomized clinical trial

This crossover, randomized, double-blind study (conducted over a 32-week period) was performed to determine, in clinically stable Cystic fibrosis (CF) preschool children: the effects of 7% inhaled hypertonic saline on spirometry and interrupter resistance technique (Rint), and the possible side effe...

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Published in:Italian journal of pediatrics 2017-07, Vol.43 (1), p.60-60, Article 60
Main Authors: Nenna, Raffaella, Midulla, Fabio, Lambiase, Caterina, De Castro, Giovanna, Zicari, Anna Maria, Indinnimeo, Luciana, Cimino, Giuseppe, Troiani, Patrizia, Quattrucci, Serena, Tancredi, Giancarlo
Format: Article
Language:English
Subjects:
Administration, Inhalation
Age
Airway management
Albuterol - administration & dosage
Anti-Asthmatic Agents - administration & dosage
Child, Preschool
Children
Children & youth
Chloride
Clinical trials
Cross-Over Studies
Cystic fibrosis
Cystic Fibrosis - physiopathology
Cystic Fibrosis - therapy
Double-Blind Method
Female
Humans
Hypertonic saline
Inhalation
Male
Mutation
Pediatrics
Respiratory Function Tests
Saline Solution, Hypertonic - administration & dosage
Sodium
Studies
Therapy
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Quattrucci, Serena
Tancredi, Giancarlo
description This crossover, randomized, double-blind study (conducted over a 32-week period) was performed to determine, in clinically stable Cystic fibrosis (CF) preschool children: the effects of 7% inhaled hypertonic saline on spirometry and interrupter resistance technique (Rint), and the possible side effects. Twelve CF children (6M, mean age ± SD: 5.7 ± 0.8 yrs) were enrolled and randomly assigned to receive hypertonic saline (HS-4 ml 7% sodium chloride), or normal saline (NS-0.9% sodium chloride) twice a day. After a 16 weeks period, therapy was exchanged to allow all the patients enrolled in the study to carry out both treatments. Monitoring visits, spirometry (COSMED Quark PFT4 ergo) and Rint were scheduled at 0,4,16,20,32 weeks. At T0, spirometric measurements and Rint were performed immediately before and 30 min after the inhalation therapy. Salbutamol (400 mcg) was administered before the drug at each visit. After a 16-weeks treatment with HS an improvement of FVC (p = 0.02) and a favorable trend of FEV1 were registered. A worsening of FEV (p 
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Twelve CF children (6M, mean age ± SD: 5.7 ± 0.8 yrs) were enrolled and randomly assigned to receive hypertonic saline (HS-4 ml 7% sodium chloride), or normal saline (NS-0.9% sodium chloride) twice a day. After a 16 weeks period, therapy was exchanged to allow all the patients enrolled in the study to carry out both treatments. Monitoring visits, spirometry (COSMED Quark PFT4 ergo) and Rint were scheduled at 0,4,16,20,32 weeks. At T0, spirometric measurements and Rint were performed immediately before and 30 min after the inhalation therapy. Salbutamol (400 mcg) was administered before the drug at each visit. After a 16-weeks treatment with HS an improvement of FVC (p = 0.02) and a favorable trend of FEV1 were registered. A worsening of FEV (p &lt; 0.0001) and of FEF25-75 (p = 0.019) were found in NS group. No differences were found in expiratory and inspiratory Rint in both groups. No serious adverse events occurred. Seven percent hypertonic saline therapy proved to be a useful and safe treatment in young CF children with clinically stable conditions. 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Twelve CF children (6M, mean age ± SD: 5.7 ± 0.8 yrs) were enrolled and randomly assigned to receive hypertonic saline (HS-4 ml 7% sodium chloride), or normal saline (NS-0.9% sodium chloride) twice a day. After a 16 weeks period, therapy was exchanged to allow all the patients enrolled in the study to carry out both treatments. Monitoring visits, spirometry (COSMED Quark PFT4 ergo) and Rint were scheduled at 0,4,16,20,32 weeks. At T0, spirometric measurements and Rint were performed immediately before and 30 min after the inhalation therapy. Salbutamol (400 mcg) was administered before the drug at each visit. After a 16-weeks treatment with HS an improvement of FVC (p = 0.02) and a favorable trend of FEV1 were registered. A worsening of FEV (p &lt; 0.0001) and of FEF25-75 (p = 0.019) were found in NS group. No differences were found in expiratory and inspiratory Rint in both groups. No serious adverse events occurred. Seven percent hypertonic saline therapy proved to be a useful and safe treatment in young CF children with clinically stable conditions. 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subjects Administration, Inhalation
Age
Airway management
Albuterol - administration & dosage
Anti-Asthmatic Agents - administration & dosage
Child, Preschool
Children
Children & youth
Chloride
Clinical trials
Cross-Over Studies
Cystic fibrosis
Cystic Fibrosis - physiopathology
Cystic Fibrosis - therapy
Double-Blind Method
Female
Humans
Hypertonic saline
Inhalation
Male
Mutation
Pediatrics
Respiratory Function Tests
Saline Solution, Hypertonic - administration & dosage
Sodium
Studies
Therapy
title Effects of inhaled hypertonic (7%) saline on lung function test in preschool children with cystic fibrosis: results of a crossover, randomized clinical trial
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