Antibacterial evaluation of some Schiff bases derived from 2-acetylpyridine and their metal complexes

A series of Schiff bases derived from 2-acetylpyridne and their metal complexes were characterized by elemental analysis, NMR, FT-IR and UV-Vis spectral studies. The complexes were screened for anti-bacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA), Acinetobacter baumanni...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2012-05, Vol.17 (5), p.5952-5971
Main Authors: Gwaram, Nura Suleiman, Ali, Hapipah Mohd, Khaledi, Hamid, Abdulla, Mahmood Ameen, Hadi, A Hamid A, Lin, Thong Kwai, Ching, Chai Lay, Ooi, Cher Lin
Format: Article
Language:English
Subjects:
anti-bacteria
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antimicrobial agents
Bacteria
Bacteria - drug effects
Cadmium
Coordination Complexes - chemistry
Copper
Electronic mail systems
Ligands
metal complexes
Microbial Sensitivity Tests
Molecular Structure
Nickel
Pyridines - chemistry
Schiff bases
Schiff Bases - chemistry
Schiff Bases - pharmacology
Staphylococcus infections
x-ray crystallography
Zinc
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Summary:A series of Schiff bases derived from 2-acetylpyridne and their metal complexes were characterized by elemental analysis, NMR, FT-IR and UV-Vis spectral studies. The complexes were screened for anti-bacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA), Acinetobacter baumanni (AC), Klebsiella pneumonie (KB) and Pseudomonas aeruginosa (PA) using the disc diffusion and micro broth dilution assays. Based on the overall results, the complexes showed the highest activities against MRSA while a weak antibacterial activity was observed against A. baumanii and P. aeruginosa.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules17055952