Impact of IFN-Free and IFN-Based Treatment on Blood Myeloid Dendritic Cell, Monocyte, Slan-DC, and Activated T Lymphocyte Dynamics during HCV Infection

Chronic hepatitis C virus infection leads to the activation of innate immunity, a key component in HCV fibrosis. In the past, the use of IFN-based treatment regimens did not permit an adequate evaluation of the impact of HCV clearance on immune cells, because of their antiviral and immunomodulatory...

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Bibliographic Details
Published in:Journal of immunology research 2020, Vol.2020 (2020), p.1-11
Main Authors: Iannetta, Marco, Zingaropoli, Maria Antonella, D'Ettorre, Gabriella, Vullo, Vincenzo, Mastroianni, Claudio Maria, Lichtner, Miriam, Tieghi, Tiziana, Marocco, Raffaella, Schiavone, Francesco, Rossi, Raffaella, Mascia, Claudia, Savinelli, Stefano, Zuccalà, Paola, Vita, Serena, Nijhawan, Parni
Format: Article
Language:English
Subjects:
Adult
Aged
Antiviral activity
Antiviral Agents - therapeutic use
Chronic infection
Dendritic cells
Dendritic Cells - immunology
Eradication
Female
Fibrosis
Genotype & phenotype
Hepacivirus - physiology
Hepatitis C
Hepatitis C, Chronic - immunology
Hepatitis C, Chronic - therapy
Humans
Immune clearance
Immune system
Immunity, Innate
Immunology
Immunomodulation
Immunotherapy - methods
Infections
Innate immunity
Interferon
Interferon-alpha - therapeutic use
Liver
Liver - pathology
Lymphocyte Activation
Lymphocytes
Lymphocytes T
Male
Middle Aged
Monocytes
Monocytes - immunology
Patients
Population
Software
Studies
T-Lymphocytes - immunology
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Summary:Chronic hepatitis C virus infection leads to the activation of innate immunity, a key component in HCV fibrosis. In the past, the use of IFN-based treatment regimens did not permit an adequate evaluation of the impact of HCV clearance on immune cells, because of their antiviral and immunomodulatory properties. The recent development of direct-acting antiviral (DAA) therapy, which is associated with high rates of sustained virological response, enables a more accurate analysis of the immunological modifications following HCV eradication. We studied the dynamics of blood myeloid dendritic cells, monocytes, slan-DCs, and T lymphocytes during IFN-free and IFN-based regimens in hepatitis C virus infection.
ISSN:2314-8861
2314-7156
DOI:10.1155/2020/2781350