Two cases of mixed large cell neuroendocrine carcinoma and adenocarcinoma of the cervix: case report and review of the literature

Mixed adenoneuroendocrine carcinoma (MANEC) of the cervix is a rare malignant tumor with high malignancy and poor prognosis, of which large-cell neuroendocrine carcinoma and HPV-independent adenocarcinoma are particularly rare, which have been reported limitedly in the literature. Here, we present 2...

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Bibliographic Details
Published in:Diagnostic pathology 2024-12, Vol.19 (1), p.166-8
Main Authors: Wei, Kang-Na, Fu, Xiao-Dan, Wang, Min-Yuan, Wang, Li-Xia
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma - diagnosis
Adenocarcinoma - pathology
Biomarkers, Tumor - analysis
Carcinoma, Large Cell - diagnosis
Carcinoma, Large Cell - pathology
Carcinoma, Neuroendocrine - diagnosis
Carcinoma, Neuroendocrine - pathology
Case Report
Cervix
Development and progression
Diagnosis
Epidemiology
Female
Gastric-type cervical adenocarcinomas
Humans
Large cell neuroendocrine carcinoma
Medical colleges
Papillomavirus infections
Prognosis
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - virology
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Summary:Mixed adenoneuroendocrine carcinoma (MANEC) of the cervix is a rare malignant tumor with high malignancy and poor prognosis, of which large-cell neuroendocrine carcinoma and HPV-independent adenocarcinoma are particularly rare, which have been reported limitedly in the literature. Here, we present 2 cases of MANEC of the cervix and discuss important considerations for diagnosing cervical poorly differentiated carcinoma. we reported two cases of mixed large cell neuroendocrine carcinoma and adenocarcinoma of the cervix, one HPV-independent and one HPV-associated, both with vaginal bleeding. Magnetic resonance imaging showed a mass-like shadow in the cervix, with varying degrees of invasion into the vagina or the lower part of the uterine body. Histologically, the tumors showed two components: solid and glandular areas, with solid areas containing nests of tumor cells and focal necrosis. In the glandular area, one showed gastric-type glandular changes, while the other showed usual-type glands. The solid area expressed CgA (1/2), Syn (2/2), and the glandular area expressed p16 (1/2), Muc-6 (1/2), MSH2 (1/2). We made a diagnosis of mixed adenoneuroendocrine carcinoma (MANEC) of the cervix and performed a literature review to better supplement epidemiological data and assist in developing standardized treatment methods.
ISSN:1746-1596
1746-1596
DOI:10.1186/s13000-024-01592-0