Two cases of mixed large cell neuroendocrine carcinoma and adenocarcinoma of the cervix: case report and review of the literature

• Published in: Diagnostic pathology 2024-12, Vol.19 (1), p.166-8, Article 166
• Main Authors: Wei, Kang-Na, Fu, Xiao-Dan, Wang, Min-Yuan, Wang, Li-Xia
• Format: Article
• Language: English
• Subjects: Adenocarcinoma; Adenocarcinoma - diagnosis; Adenocarcinoma - pathology; Biomarkers, Tumor - analysis; Carcinoma, Large Cell - diagnosis; Carcinoma, Large Cell - pathology; Carcinoma, Neuroendocrine - diagnosis; Carcinoma, Neuroendocrine - pathology; Case Report; Cervix; Development and progression; Diagnosis; Epidemiology; Female; Gastric-type cervical adenocarcinomas; Humans; Large cell neuroendocrine carcinoma; Medical colleges; Papillomavirus infections; Prognosis; Uterine Cervical Neoplasms - pathology; Uterine Cervical Neoplasms - virology
• ISSN: 1746-1596; 1746-1596
• DOI: 10.1186/s13000-024-01592-0

Mixed adenoneuroendocrine carcinoma (MANEC) of the cervix is a rare malignant tumor with high malignancy and poor prognosis, of which large-cell neuroendocrine carcinoma and HPV-independent adenocarcinoma are particularly rare, which have been reported limitedly in the literature. Here, we present 2 cases of MANEC of the cervix and discuss important considerations for diagnosing cervical poorly differentiated carcinoma. we reported two cases of mixed large cell neuroendocrine carcinoma and adenocarcinoma of the cervix, one HPV-independent and one HPV-associated, both with vaginal bleeding. Magnetic resonance imaging showed a mass-like shadow in the cervix, with varying degrees of invasion into the vagina or the lower part of the uterine body. Histologically, the tumors showed two components: solid and glandular areas, with solid areas containing nests of tumor cells and focal necrosis. In the glandular area, one showed gastric-type glandular changes, while the other showed usual-type glands. The solid area expressed CgA (1/2), Syn (2/2), and the glandular area expressed p16 (1/2), Muc-6 (1/2), MSH2 (1/2). We made a diagnosis of mixed adenoneuroendocrine carcinoma (MANEC) of the cervix and performed a literature review to better supplement epidemiological data and assist in developing standardized treatment methods.