The effect of non-optimal lipids on the progression of coronary artery calcification in statin-naïve young adults: results from KOICA registry

Despite the importance of attaining optimal lipid levels from a young age to secure long-term cardiovascular health, the detailed impact of non-optimal lipid levels in young adults on coronary artery calcification (CAC) is not fully explored. We sought to investigate the risk of CAC progression as p...

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Published in:Frontiers in cardiovascular medicine 2023-07, Vol.10, p.1173289-1173289
Main Authors: Lee, Heesun, Ahn, Hyo-Jeong, Park, Hyo Eun, Han, Donghee, Chang, Hyuk-Jae, Chun, Eun Ju, Han, Hae-Won, Sung, Jidong, Jung, Hae Ok, Choi, Su-Yeon
Format: Article
Language:English
Subjects:
atherosclerosis
Cardiovascular Medicine
coronary calcification
dyslipidemia
prevention
young adults
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Summary:Despite the importance of attaining optimal lipid levels from a young age to secure long-term cardiovascular health, the detailed impact of non-optimal lipid levels in young adults on coronary artery calcification (CAC) is not fully explored. We sought to investigate the risk of CAC progression as per lipid profiles and to demonstrate lipid optimality in young adults. From the KOrea Initiative on Coronary Artery calcification (KOICA) registry that was established in six large volume healthcare centers in Korea, 2,940 statin-naïve participants aged 20-45 years who underwent serial coronary calcium scans for routine health check-ups between 2002 and 2017 were included. The study outcome was CAC progression, which was assessed by the square root method. The risk of CAC progression was analyzed according to the lipid optimality and each lipid parameter. In this retrospective cohort (mean age, 41.3 years; men 82.4%), 477 participants (16.2%) had an optimal lipid profile, defined as triglycerides
ISSN:2297-055X
2297-055X
DOI:10.3389/fcvm.2023.1173289