Positive Correlation between Relative Concentration of Spermine to Spermidine in Whole Blood and Skeletal Muscle Mass Index: A Possible Indicator of Sarcopenia and Prognosis of Hemodialysis Patients

Several mechanisms strictly regulate polyamine concentration, and blood polyamines are excreted in urine. This indicates polyamine accumulation in renal dysfunction, and studies have shown increased blood polyamine concentrations in patients with renal failure. Hemodialysis (HD) may compensate for p...

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Published in:Biomedicines 2023-03, Vol.11 (3), p.746
Main Authors: Sanayama, Hidenori, Ito, Kiyonori, Ookawara, Susumu, Uemura, Takeshi, Imai, Sojiro, Kiryu, Satoshi, Iguchi, Miho, Sakiyama, Yoshio, Sugawara, Hitoshi, Morishita, Yoshiyuki, Tabei, Kaoru, Igarashi, Kazuei, Soda, Kuniyasu
Format: Article
Language:English
Subjects:
Adults
Age
Albumin
Automation
Blood
Blood levels
Cancer
Creatinine
Dialysate
Enzymes
Excretion
Hemodialysis
Hemoglobin
Hospitals
Laboratories
Musculoskeletal system
Physiological aspects
polyamine
Polyamines
Prognosis
Renal failure
Renal function
Risk factors
Sarcopenia
Skeletal muscle
Spermidine
Spermine
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Summary:Several mechanisms strictly regulate polyamine concentration, and blood polyamines are excreted in urine. This indicates polyamine accumulation in renal dysfunction, and studies have shown increased blood polyamine concentrations in patients with renal failure. Hemodialysis (HD) may compensate for polyamine excretion; however, little is known about polyamine excretion. We measured whole-blood polyamine levels in patients on HD and examined the relationship between polyamine concentrations and indicators associated with health status. Study participants were 59 hemodialysis patients (median age: 70.0 years) at Minami-Uonuma City Hospital and 26 healthy volunteers (median age: 44.5 years). Whole-blood spermidine levels were higher and spermine/spermidine ratio (SPM/SPD) was lower in hemodialysis patients. Hemodialysis showed SPD efflux into the dialysate; however, blood polyamine levels were not altered by hemodialysis and appeared to be minimally excreted. The skeletal muscle mass index (SMI), which was positively correlated with hand grip strength and serum albumin level, was positively correlated with SPM/SPD. Given that sarcopenia and low serum albumin levels are reported risk factors for poor prognosis in HD patients, whole blood SPM/SPD in hemodialysis patients may be a new indicator of the prognosis and health status of HD patients.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines11030746