Pretreatment CT Texture Parameters as Predictive Biomarkers of Progression-Free Survival in Follicular Lymphoma Treated with Immunochemotherapy and Rituximab Maintenance

The purpose of this study was to determine whether texture analysis features present on pretreatment unenhanced computed tomography (CT) images, derived from 18F-fluorodeoxyglucose positron emission/computed tomography (18-FDG PET/CT), can predict progression-free survival (PFS), progression-free su...

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Bibliographic Details
Published in:Diagnostics (Basel) 2023-06, Vol.13 (13), p.2237
Main Authors: Durot, Carole, Durot, Eric, Mulé, Sébastien, Morland, David, Godard, François, Quinquenel, Anne, Delmer, Alain, Soyer, Philippe, Hoeffel, Christine
Format: Article
Language:English
Subjects:
Biological markers
Biomarkers
Cable television broadcasting industry
Care and treatment
Computer Science
CT imaging
Development and progression
follicular lymphoma
Kurtosis
Lymphatic system
Lymphoma
Medical Imaging
Metabolism
Non-Hodgkin's lymphomas
Nuclear medicine
Patients
PET imaging
positron emission tomography
Prognosis
Software
Tomography
X-ray computed
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Summary:The purpose of this study was to determine whether texture analysis features present on pretreatment unenhanced computed tomography (CT) images, derived from 18F-fluorodeoxyglucose positron emission/computed tomography (18-FDG PET/CT), can predict progression-free survival (PFS), progression-free survival at 24 months (PFS 24), time to next treatment (TTNT), and overall survival in patients with high-tumor-burden follicular lymphoma treated with immunochemotherapy and rituximab maintenance. Seventy-two patients with follicular lymphoma were retrospectively included. Texture analysis was performed on unenhanced CT images extracted from 18-FDG PET/CT examinations that were obtained within one month before treatment. Skewness at a fine texture scale (SSF = 2) was an independent predictor of PFS (hazard ratio = 3.72 (95% CI: 1.15, 12.11), = 0.028), PFS 24 (hazard ratio = 13.38; 95% CI: 1.29, 138.13; = 0.029), and TTNT (hazard ratio = 5.11; 95% CI: 1.18, 22.13; = 0.029). Skewness values above -0.015 at SSF = 2 were significantly associated with lower PFS, PFS 24, and TTNT. Kurtosis without filtration was an independent predictor of PFS (SSF = 0; HR = 1.22 (95% CI: 1.04, 1.44), = 0.013), and TTNT (SSF = 0; hazard ratio = 1.23; 95% CI: 1.04, 1.46; = 0.013). This study shows that pretreatment unenhanced CT texture analysis-derived tumor skewness and kurtosis may be used as predictive biomarkers of PFS and TTNT in patients with high-tumor-burden follicular lymphoma treated with immunochemotherapy and rituximab maintenance.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics13132237