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Effect of Fufang Huangqi Decoction on the Gut Microbiota in Patients With Class I or II Myasthenia Gravis

To investigate the effect of Fufang Huangqi Decoction on the gut microbiota in patients with class I or II myasthenia gravis (MG) and to explore the correlation between gut microbiota and MG (registration number, ChiCTR2100048367; registration website, http://www.chictr.org.cn/listbycreater.aspx; NC...

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Bibliographic Details
Published in:Frontiers in neurology 2022-03, Vol.13, p.785040-785040
Main Authors: Chen, Yanghong, Lin, Yi, Shan, Caifeng, Li, Zhaoqing, Xiao, Bo, He, Rencai, Huang, Xueshi, Wang, Zhanyou, Zhang, Jingsheng, Qiao, Wenjun
Format: Article
Language:English
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Summary:To investigate the effect of Fufang Huangqi Decoction on the gut microbiota in patients with class I or II myasthenia gravis (MG) and to explore the correlation between gut microbiota and MG (registration number, ChiCTR2100048367; registration website, http://www.chictr.org.cn/listbycreater.aspx; NCBI: SRP338707). In this study, microbial community composition and diversity analyses were carried out on fecal specimens from MG patients who did not take Fufang Huangqi Decoction (control group, = 8) and those who took Fufang Huangqi Decoction and achieved remarkable alleviation of symptoms (medication group, = 8). The abundance, diversity within and between habitats, taxonomic differences and corresponding discrimination markers of gut microbiota in the control group and medicated group were assessed. Compared with the control group, the medicated group showed a significantly decreased abundance of Bacteroidetes ( < 0.05) and significantly increased abundance of Actinobacteria at the phylum level, a significantly decreased abundance of Bacteroidaceae ( < 0.05) and significantly increased abundance of Bifidobacteriaceae at the family level and a significantly decreased abundance of and ( < 0.05) and significantly increased abundance of and at the genus level. Compared to the control group, the medicated group had decreased abundance, diversity, and genetic diversity of the communities and increased coverage, but the differences were not significant ( > 0.05); the markers that differed significantly between communities at the genus level and influenced the differences between groups were and . MG patients have obvious gut microbiota-associated metabolic disorders. Fufang Huangqi Decoction regulates the gut microbiota in patients with class I or II MG by reducing the abundance of and and increasing the abundance of and . The correlation between gut microbiota and MG may be related to cell-mediated immunity.
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2022.785040