MD simulation of high-resolution X-ray structures reveals post-translational modification dependent conformational changes in HSF-DNA interaction

Dear Editor, Heat shock factors （HSFs） constitute a transcription factor family playing regulatory roles in maintaining cellular protein homeostasis or mediating cell differentiation and develop- ment （Akerfelt et al., 2010, Bjork and Sistonen 2010, Westerheide et al., 2012）. Some human diseases suc...

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Published in:Protein & cell 2016-12, Vol.7 (12), p.916-920
Main Authors: Feng, Han, Wang, Sheng, Guo, Ling, Punekar, Avinash S., Ladenstein, Rudolf, Wang, Da-Cheng, Liu, Wei
Format: Article
Language:English
Subjects:
Attenuation Phase
Biochemistry
Biomedical and Life Sciences
Cell Biology
Developmental Biology
Human Genetics
Letter
Life Sciences
Major Groove
Minor Groove
Protein Science
Significant Conformational Change
Stem Cells
Sumo Modification
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Summary:Dear Editor, Heat shock factors （HSFs） constitute a transcription factor family playing regulatory roles in maintaining cellular protein homeostasis or mediating cell differentiation and develop- ment （Akerfelt et al., 2010, Bjork and Sistonen 2010, Westerheide et al., 2012）. Some human diseases such as cancer and neurodegeneration are often linked with mal- function of HSFs （Dai et al., 2007, Neef et al., 2011, Scherz- Shouval et al., 2014）. The human HSF family consists four members： HSF1-4, which exhibit tissue-specific expression profiles and possess unique but overlapping functions. HSF1 is the major regulator of the heat shock response.
ISSN:1674-800X
1674-8018
DOI:10.1007/s13238-016-0331-0