Healthy Gut, Healthy Bones: Targeting the Gut Microbiome to Promote Bone Health

Over the past decade, the use of probiotics to modify the gut microbiome has become a public spotlight in reducing the severity of a number of chronic diseases such as autoimmune disease, diabetes, cancer and cardiovascular disease. Recently, the gut microbiome has been shown to play an important ro...

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Bibliographic Details
Published in:Frontiers in endocrinology (Lausanne) 2021-02, Vol.11, p.620466-620466
Main Authors: Cooney, Olivia D, Nagareddy, Prabhakar R, Murphy, Andrew J, Lee, Man K S
Format: Article
Language:English
Subjects:
Animals
bone
Bone Density - drug effects
Bone Density - physiology
Capillary Permeability - drug effects
Capillary Permeability - physiology
Endocrinology
Gastrointestinal Diseases - epidemiology
Gastrointestinal Diseases - metabolism
Gastrointestinal Diseases - therapy
Gastrointestinal Microbiome - drug effects
Gastrointestinal Microbiome - physiology
gut
Humans
microbiome
Osteoporosis - epidemiology
Osteoporosis - metabolism
Osteoporosis - therapy
Probiotics - administration & dosage
short chain fatty acid
Th17 & Tregs cells
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Summary:Over the past decade, the use of probiotics to modify the gut microbiome has become a public spotlight in reducing the severity of a number of chronic diseases such as autoimmune disease, diabetes, cancer and cardiovascular disease. Recently, the gut microbiome has been shown to play an important role in regulating bone mass. Therefore, targeting the gut microbiome may be a potential alternative avenue for those with osteopenia or osteoporosis. In this mini-review, we take the opportunity to delve into how the different components of the gut work together and how the gut-related diseases impact on bone health.
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2020.620466