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Signalling couples hair follicle stem cell quiescence with reduced histone H3 K4/K9/K27me3 for proper tissue homeostasis
Mechanisms of plasticity to acquire different cell fates are critical for adult stem cell (SC) potential, yet are poorly understood. Reduced global histone methylation is an epigenetic state known to mediate plasticity in cultured embryonic SCs and T-cell progenitors. Here we find histone H3 K4/K9/K...
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| Published in: | Nature communications 2016-04, Vol.7 (1), p.11278-11278, Article 11278 |
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| creator | Lee, Jayhun Kang, Sangjo Lilja, Karin C. Colletier, Keegan J. Scheitz, Cornelia Johanna Franziska Zhang, Ying V. Tumbar, Tudorita |
| description | Mechanisms of plasticity to acquire different cell fates are critical for adult stem cell (SC) potential, yet are poorly understood. Reduced global histone methylation is an epigenetic state known to mediate plasticity in cultured embryonic SCs and T-cell progenitors. Here we find histone H3 K4/K9/K27me3 levels actively reduced in adult mouse skin and hair follicle stem cells (HFSCs) during G0 quiescence. The level of marks over specific gene promoters did not correlate to mRNA level changes in quiescent HFSCs. Skin hypomethylation during quiescence was necessary for subsequent progression of hair homeostasis (cycle). Inhibiting BMP signal, a known HFSC anti-proliferative factor, elevated HFSC methylation
in vivo
during quiescence prior to proliferation onset. Furthermore, removal of proliferation factors and addition of BMP4 reduced histone methylases and increased demethylases mRNAs in cultured skin epithelial cells. We conclude that signalling couples hair follicle stem cell quiescence with reduced H3 K4/K9/K27me3 levels for proper tissue homeostasis.
Changes in global histone trimethylation have been linked to embryonic but not adult stem cell plasticity. Here, Lee
et al
. find H3 K4/K9/K27me3 levels actively reduced in adult mouse skin and hair follicle stem cells during quiescence (catagen) and link this to active bone morphogen protein signalling. |
| doi_str_mv | 10.1038/ncomms11278 |
| format | article |
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in vivo
during quiescence prior to proliferation onset. Furthermore, removal of proliferation factors and addition of BMP4 reduced histone methylases and increased demethylases mRNAs in cultured skin epithelial cells. We conclude that signalling couples hair follicle stem cell quiescence with reduced H3 K4/K9/K27me3 levels for proper tissue homeostasis.
Changes in global histone trimethylation have been linked to embryonic but not adult stem cell plasticity. Here, Lee
et al
. find H3 K4/K9/K27me3 levels actively reduced in adult mouse skin and hair follicle stem cells during quiescence (catagen) and link this to active bone morphogen protein signalling.</description><identifier>ISSN: 2041-1723</identifier><identifier>EISSN: 2041-1723</identifier><identifier>DOI: 10.1038/ncomms11278</identifier><identifier>PMID: 27080563</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/100 ; 13/31 ; 14/63 ; 631/136/532/2443 ; 631/337/100/2285 ; 631/443/319/1557 ; 631/80/86 ; 64/60 ; 82/51 ; 96/1 ; Animals ; Animals, Newborn ; Blotting, Western ; Bone Morphogenetic Proteins - metabolism ; Cell division ; Cells, Cultured ; Epigenetics ; Female ; Follicles ; Gene Expression ; Genomes ; Hair - cytology ; Hair - metabolism ; Hair Follicle - cytology ; Hair Follicle - metabolism ; Histones - metabolism ; Homeostasis ; Humanities and Social Sciences ; Male ; Methylation ; Mice, 129 Strain ; Microscopy, Fluorescence ; multidisciplinary ; Resting Phase, Cell Cycle ; Reverse Transcriptase Polymerase Chain Reaction ; Science ; Science (multidisciplinary) ; Signal Transduction ; Skin - cytology ; Skin - metabolism ; Stem cells ; Stem Cells - cytology ; Stem Cells - metabolism</subject><ispartof>Nature communications, 2016-04, Vol.7 (1), p.11278-11278, Article 11278</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Apr 2016</rights><rights>Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2016 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c363t-a515effe45020868f8c30c96a64fc45890e1a57e7c75b562410de78690e22a753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1781159234/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1781159234?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,74998</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27080563$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Jayhun</creatorcontrib><creatorcontrib>Kang, Sangjo</creatorcontrib><creatorcontrib>Lilja, Karin C.</creatorcontrib><creatorcontrib>Colletier, Keegan J.</creatorcontrib><creatorcontrib>Scheitz, Cornelia Johanna Franziska</creatorcontrib><creatorcontrib>Zhang, Ying V.</creatorcontrib><creatorcontrib>Tumbar, Tudorita</creatorcontrib><title>Signalling couples hair follicle stem cell quiescence with reduced histone H3 K4/K9/K27me3 for proper tissue homeostasis</title><title>Nature communications</title><addtitle>Nat Commun</addtitle><addtitle>Nat Commun</addtitle><description>Mechanisms of plasticity to acquire different cell fates are critical for adult stem cell (SC) potential, yet are poorly understood. Reduced global histone methylation is an epigenetic state known to mediate plasticity in cultured embryonic SCs and T-cell progenitors. Here we find histone H3 K4/K9/K27me3 levels actively reduced in adult mouse skin and hair follicle stem cells (HFSCs) during G0 quiescence. The level of marks over specific gene promoters did not correlate to mRNA level changes in quiescent HFSCs. Skin hypomethylation during quiescence was necessary for subsequent progression of hair homeostasis (cycle). Inhibiting BMP signal, a known HFSC anti-proliferative factor, elevated HFSC methylation
in vivo
during quiescence prior to proliferation onset. Furthermore, removal of proliferation factors and addition of BMP4 reduced histone methylases and increased demethylases mRNAs in cultured skin epithelial cells. We conclude that signalling couples hair follicle stem cell quiescence with reduced H3 K4/K9/K27me3 levels for proper tissue homeostasis.
Changes in global histone trimethylation have been linked to embryonic but not adult stem cell plasticity. Here, Lee
et al
. find H3 K4/K9/K27me3 levels actively reduced in adult mouse skin and hair follicle stem cells during quiescence (catagen) and link this to active bone morphogen protein signalling.</description><subject>13/100</subject><subject>13/31</subject><subject>14/63</subject><subject>631/136/532/2443</subject><subject>631/337/100/2285</subject><subject>631/443/319/1557</subject><subject>631/80/86</subject><subject>64/60</subject><subject>82/51</subject><subject>96/1</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Blotting, Western</subject><subject>Bone Morphogenetic Proteins - metabolism</subject><subject>Cell division</subject><subject>Cells, Cultured</subject><subject>Epigenetics</subject><subject>Female</subject><subject>Follicles</subject><subject>Gene Expression</subject><subject>Genomes</subject><subject>Hair - cytology</subject><subject>Hair - metabolism</subject><subject>Hair Follicle - cytology</subject><subject>Hair Follicle - metabolism</subject><subject>Histones - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Nature communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Jayhun</au><au>Kang, Sangjo</au><au>Lilja, Karin C.</au><au>Colletier, Keegan J.</au><au>Scheitz, Cornelia Johanna Franziska</au><au>Zhang, Ying V.</au><au>Tumbar, Tudorita</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Signalling couples hair follicle stem cell quiescence with reduced histone H3 K4/K9/K27me3 for proper tissue homeostasis</atitle><jtitle>Nature communications</jtitle><stitle>Nat Commun</stitle><addtitle>Nat Commun</addtitle><date>2016-04-15</date><risdate>2016</risdate><volume>7</volume><issue>1</issue><spage>11278</spage><epage>11278</epage><pages>11278-11278</pages><artnum>11278</artnum><issn>2041-1723</issn><eissn>2041-1723</eissn><abstract>Mechanisms of plasticity to acquire different cell fates are critical for adult stem cell (SC) potential, yet are poorly understood. Reduced global histone methylation is an epigenetic state known to mediate plasticity in cultured embryonic SCs and T-cell progenitors. Here we find histone H3 K4/K9/K27me3 levels actively reduced in adult mouse skin and hair follicle stem cells (HFSCs) during G0 quiescence. The level of marks over specific gene promoters did not correlate to mRNA level changes in quiescent HFSCs. Skin hypomethylation during quiescence was necessary for subsequent progression of hair homeostasis (cycle). Inhibiting BMP signal, a known HFSC anti-proliferative factor, elevated HFSC methylation
in vivo
during quiescence prior to proliferation onset. Furthermore, removal of proliferation factors and addition of BMP4 reduced histone methylases and increased demethylases mRNAs in cultured skin epithelial cells. We conclude that signalling couples hair follicle stem cell quiescence with reduced H3 K4/K9/K27me3 levels for proper tissue homeostasis.
Changes in global histone trimethylation have been linked to embryonic but not adult stem cell plasticity. Here, Lee
et al
. find H3 K4/K9/K27me3 levels actively reduced in adult mouse skin and hair follicle stem cells during quiescence (catagen) and link this to active bone morphogen protein signalling.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27080563</pmid><doi>10.1038/ncomms11278</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 13/100 13/31 14/63 631/136/532/2443 631/337/100/2285 631/443/319/1557 631/80/86 64/60 82/51 96/1 Animals Animals, Newborn Blotting, Western Bone Morphogenetic Proteins - metabolism Cell division Cells, Cultured Epigenetics Female Follicles Gene Expression Genomes Hair - cytology Hair - metabolism Hair Follicle - cytology Hair Follicle - metabolism Histones - metabolism Homeostasis Humanities and Social Sciences Male Methylation Mice, 129 Strain Microscopy, Fluorescence multidisciplinary Resting Phase, Cell Cycle Reverse Transcriptase Polymerase Chain Reaction Science Science (multidisciplinary) Signal Transduction Skin - cytology Skin - metabolism Stem cells Stem Cells - cytology Stem Cells - metabolism |
| title | Signalling couples hair follicle stem cell quiescence with reduced histone H3 K4/K9/K27me3 for proper tissue homeostasis |
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