Contribution of momilactones A and B to diabetes inhibitory potential of rice bran: Evidence from in vitro assays

This study was the first to detect the presence of the two compounds momilactone A (MA) and momilactone B (MB) in rice bran using liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS). By in vitro assays, both MA and MB exhibited potent inhibitory activities on pancreatic α-amy...

Full description

Saved in:
Bibliographic Details
Published in:Saudi pharmaceutical journal 2019-07, Vol.27 (5), p.643-649
Main Authors: Quan, Nguyen Van, Xuan, Tran Dang, Tran, Hoang-Dung, Ahmad, Ateeque, Khanh, Tran Dang, Dat, Tran Dang
Format: Article
Language:English
Subjects:
Anti-diabetes
HPLC and LC-ESI-MS methods
Momilactones A and B
Rice bran
Trypsin
α-amylase
α-glucosidase
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study was the first to detect the presence of the two compounds momilactone A (MA) and momilactone B (MB) in rice bran using liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS). By in vitro assays, both MA and MB exhibited potent inhibitory activities on pancreatic α-amylase and α-glucosidase which were significantly higher than γ-oryzanol, a well-known diabetes inhibitor. Remarkably, MA and MB indicated an effective inhibition on trypsin with the IC50 values of 921.55 and 884.03 µg/mL, respectively. By high-performance liquid chromatography (HPLC), quantities of MA (6.65 µg/g dry weight) and MB (6.24 µg/g dry weight) in rice bran were determined. Findings of this study revealed the α-amylase, α-glucosidase and trypsin inhibitors MA and MB contributed an active role to the diabetes inhibitory potential of rice bran.
ISSN:1319-0164
2213-7475
DOI:10.1016/j.jsps.2019.03.006