A Prognostic Gene Signature for Hepatocellular Carcinoma

Hepatocellular carcinoma is the third most common cause of cancer-related deaths in China and immune-based therapy can improve patient outcomes. In this study, we investigated the relationship between immunity-associated genes and hepatocellular carcinoma from the prognostic perspective. The data do...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in oncology 2022-04, Vol.12, p.841530-841530
Main Authors: Chen, Rong, Zhao, Meng, An, Yanli, Liu, Dongfang, Tang, Qiusha, Teng, Gaojun
Format: Article
Language:English
Subjects:
bioinformatics analysis
gene signature
hepatocellular carcinoma
immune cells
immune-related prognostic genes
Oncology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hepatocellular carcinoma is the third most common cause of cancer-related deaths in China and immune-based therapy can improve patient outcomes. In this study, we investigated the relationship between immunity-associated genes and hepatocellular carcinoma from the prognostic perspective. The data downloaded from The Cancer Genome Atlas Liver Hepatocellular Carcinoma (TCGA-LIHC) and the Gene Expression Omnibus (GEO) was screened for gene mutation frequency using the maftools package. Immunity-associated eight-gene signature with strong prognostic ability was constructed and proved as an independent predictor of the patient outcome in LIHC. Seven genes in the immune-related eight-gene signature were strongly associated with the infiltration of M0 macrophages, resting mast cells, and regulatory T cells. Our research may provide clinicians with a quantitative method to predict the prognosis of patients with liver cancer, which can assist in the selection of the optimal treatment plan.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2022.841530