Endothelial Dysfunction Correlates with Liver Fibrosis in Chronic HCV Infection

Background. Hepatitis C virus (HCV) infection can exert proatherogenic activities due to its direct action on vessel walls and/or via the chronic inflammatory process involving the liver. Aims. To clarify the role of HCV in atherosclerosis development in monoinfected HCV patients at different degree...

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Published in:Gastroenterology research and practice 2015-01, Vol.2015 (2015), p.1-7
Main Authors: Di Leo, Alfredo, Scicchitano, Pietro, Ciccone, Marco Matteo, Gesualdo, Michele, Cortese, Francesca, Devito, Fiorella, Zito, Annapaola, Schiraldi, Serafina, Amoruso, Annabianca, Viggiani, Maria Teresa, Barone, Michele, Brunetti, Natale Daniele
Format: Article
Language:English
Subjects:
Atherosclerosis
Autoimmune diseases
C-reactive protein
Cardiovascular disease
Care and treatment
Complications and side effects
Coronary vessels
Diabetes
Endothelium
Fibrosis
Gastroenterology
Hepatitis
Hepatitis C
Hypertension
Infections
Influence
Liver cancer
Liver cirrhosis
Liver diseases
Morphology
Physiological aspects
Population
Risk factors
Studies
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Summary:Background. Hepatitis C virus (HCV) infection can exert proatherogenic activities due to its direct action on vessel walls and/or via the chronic inflammatory process involving the liver. Aims. To clarify the role of HCV in atherosclerosis development in monoinfected HCV patients at different degrees of liver fibrosis and with no risk factors for coronary artery disease. Methods. Forty-five patients were included. Clinical, serological, and anthropometric parameters, liver fibrosis (transient liver elastometry (fibroscan) and aspartate aminotransferase to platelet ratio index (APRI)), carotid intima-media thickness (c-IMT), and brachial artery flow-mediated vasodilatation (FMD) were assessed. Patients were divided into 3 tertiles according to fibroscan values. Results. Patients in the third tertile (fibroscan value >11.5 KPa) showed FMD values were significantly lower than second and first tertiles ( 4.7 ± 1.7 % versus 7.1 ± 2.8 % , p = 0.03 ). FMD values were inversely related to liver elastomeric values. c-IMT values were normal. The risk for endothelial dysfunction development in the third tertile ( p = 0.02 ) was 6.9 higher than the first tertile. A fibroscan value >11.5 KPa had a positive predictive power equal to 79% for endothelial dysfunction. Conclusions. HCV advanced liver fibrosis promotes atherosclerosis by inducing endothelial dysfunction independently of common cardiovascular risk factors.
ISSN:1687-6121
1687-630X
DOI:10.1155/2015/682174