The spectrum of comorbidities at the initial diagnosis of heart failure a case control study

The prognosis of heart failure (HF) patients is determined to a decisive extent by comorbidities. The present study investigates the association between a broad spectrum of diseases and the occurrence of HF in a large collective of outpatients. This retrospective case control study assessed the prev...

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Bibliographic Details
Published in:Scientific reports 2022-02, Vol.12 (1), p.2670-2670, Article 2670
Main Authors: Loosen, Sven H., Roderburg, Christoph, Curth, Ole, Gaensbacher, Julia, Joerdens, Markus, Luedde, Tom, Konrad, Marcel, Kostev, Karel, Luedde, Mark
Format: Article
Language:English
Subjects:
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Aged
Aged, 80 and over
Bronchitis
Chronic obstructive pulmonary disease
Comorbidity
Congestive heart failure
Coronary artery disease
Diabetes mellitus
Diagnosis
Disease
Female
Germany
Gout
Heart failure
Heart Failure - diagnosis
Heart Failure - epidemiology
Heart Failure - physiopathology
Humanities and Social Sciences
Humans
Hypertension
Kidney diseases
Lipid metabolism
Male
Middle Aged
Models, Cardiovascular
multidisciplinary
Patients
Registries
Regression analysis
Retrospective Studies
Science
Science (multidisciplinary)
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Summary:The prognosis of heart failure (HF) patients is determined to a decisive extent by comorbidities. The present study investigates the association between a broad spectrum of diseases and the occurrence of HF in a large collective of outpatients. This retrospective case control study assessed the prevalence of 37 cardiac and extracardiac diseases in patients with an initial diagnosis of heart failure (ICD-10: I50) in 1,274 general practices in Germany between January 2005 and December 2019. The study is based on the Disease Analyzer database (IQVIA), which contains drug prescriptions, diagnoses, and basic medical and demographic data. Patients with and without heart failure were matched by sex, age, and index year. Hazard regression models were conducted to evaluate the association between different disease entities and heart failure. The present study included 162,246 patients with heart failure and 162,246 patients without heart failure. Mean age [SD] was 73.7 [12.1] years; 52.6% were women. Out of 37 predefined diagnoses, 36 were more prevalent in HF patients. The highest prevalence was primary hypertension (63.4% in HF patients vs. 53.3% in controls, p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-06618-5