Azithromycin Prevents Pregnancy Loss: Reducing the Level of Tumor Necrosis Factor-Alpha and Raising the Level of Interleukin-10 in Rats

The aim of this study was to determine the effect of azithromycin on LPS-induced pregnancy loss. Thirty-six pregnant female Wistar rats were divided into 4 equal groups as follows: control group, where 0.3 mL of normal saline solution was administered intravenously on day 10 of pregnancy; azithromyc...

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Bibliographic Details
Published in:Mediators of Inflammation 2013-01, Vol.2013 (2013), p.310-314
Main Author: Er, Ayse
Format: Article
Language:English
Subjects:
Abortion, Septic - immunology
Abortion, Septic - prevention & control
Animals
Anti-Bacterial Agents - therapeutic use
Azithromycin
Azithromycin - therapeutic use
Female
Health aspects
Interleukin-10
Interleukin-10 - blood
Lipopolysaccharides - toxicity
Male
Miscarriage
Physiological aspects
Pregnancy
Prevention
Rats
Rats, Wistar
Tumor necrosis factor
Tumor Necrosis Factor-alpha - blood
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Summary:The aim of this study was to determine the effect of azithromycin on LPS-induced pregnancy loss. Thirty-six pregnant female Wistar rats were divided into 4 equal groups as follows: control group, where 0.3 mL of normal saline solution was administered intravenously on day 10 of pregnancy; azithromycin group, where azithromycin was administered orally at 350 mg kg−1 day on days 9, 10, and 11 of pregnancy; lipopolysaccharide group, where LPS was administered intravenously via the tail vein at 160 μg kg−1 on day 10 of pregnancy; and the azithromycin + LPS group, where azithromycin was administered orally at 350 mg kg−1 day on days 9, 10, and 11 of pregnancy and LPS was administered intravenously at 160 μg kg−1 on day 10 of pregnancy. Blood samples were obtained from the tail vein on day 10 of the experiment. Pregnancy rates were determined. Tumor necrosis factor-alpha (TNF-α) and interleukin (IL-10) levels were measured by ELISA. Azithromycin prevented (P
ISSN:0962-9351
1466-1861
DOI:10.1155/2013/928137