Azithromycin Prevents Pregnancy Loss: Reducing the Level of Tumor Necrosis Factor-Alpha and Raising the Level of Interleukin-10 in Rats

The aim of this study was to determine the effect of azithromycin on LPS-induced pregnancy loss. Thirty-six pregnant female Wistar rats were divided into 4 equal groups as follows: control group, where 0.3 mL of normal saline solution was administered intravenously on day 10 of pregnancy; azithromyc...

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Published in:Mediators of Inflammation 2013-01, Vol.2013 (2013), p.310-314
Main Author: Er, Ayse
Format: Article
Language:English
Subjects:
Abortion, Septic - immunology
Abortion, Septic - prevention & control
Animals
Anti-Bacterial Agents - therapeutic use
Azithromycin
Azithromycin - therapeutic use
Female
Health aspects
Interleukin-10
Interleukin-10 - blood
Lipopolysaccharides - toxicity
Male
Miscarriage
Physiological aspects
Pregnancy
Prevention
Rats
Rats, Wistar
Tumor necrosis factor
Tumor Necrosis Factor-alpha - blood
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description The aim of this study was to determine the effect of azithromycin on LPS-induced pregnancy loss. Thirty-six pregnant female Wistar rats were divided into 4 equal groups as follows: control group, where 0.3 mL of normal saline solution was administered intravenously on day 10 of pregnancy; azithromycin group, where azithromycin was administered orally at 350 mg kg−1 day on days 9, 10, and 11 of pregnancy; lipopolysaccharide group, where LPS was administered intravenously via the tail vein at 160 μg kg−1 on day 10 of pregnancy; and the azithromycin + LPS group, where azithromycin was administered orally at 350 mg kg−1 day on days 9, 10, and 11 of pregnancy and LPS was administered intravenously at 160 μg kg−1 on day 10 of pregnancy. Blood samples were obtained from the tail vein on day 10 of the experiment. Pregnancy rates were determined. Tumor necrosis factor-alpha (TNF-α) and interleukin (IL-10) levels were measured by ELISA. Azithromycin prevented (P
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Thirty-six pregnant female Wistar rats were divided into 4 equal groups as follows: control group, where 0.3 mL of normal saline solution was administered intravenously on day 10 of pregnancy; azithromycin group, where azithromycin was administered orally at 350 mg kg−1 day on days 9, 10, and 11 of pregnancy; lipopolysaccharide group, where LPS was administered intravenously via the tail vein at 160 μg kg−1 on day 10 of pregnancy; and the azithromycin + LPS group, where azithromycin was administered orally at 350 mg kg−1 day on days 9, 10, and 11 of pregnancy and LPS was administered intravenously at 160 μg kg−1 on day 10 of pregnancy. Blood samples were obtained from the tail vein on day 10 of the experiment. Pregnancy rates were determined. Tumor necrosis factor-alpha (TNF-α) and interleukin (IL-10) levels were measured by ELISA. Azithromycin prevented (P&lt;0.05) LPS-induced pregnancy loss. Higher TNF-α and IL-10 levels were measured (P&lt;0.05) in the LPS and azithromycin + LPS groups, respectively. In conclusion, azithromycin may be useful in infection- or endotoxemia-dependent pregnancy loss.</description><identifier>ISSN: 0962-9351</identifier><identifier>EISSN: 1466-1861</identifier><identifier>DOI: 10.1155/2013/928137</identifier><identifier>PMID: 24371377</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Limiteds</publisher><subject>Abortion, Septic - immunology ; Abortion, Septic - prevention &amp; control ; Animals ; Anti-Bacterial Agents - therapeutic use ; Azithromycin ; Azithromycin - therapeutic use ; Female ; Health aspects ; Interleukin-10 ; Interleukin-10 - blood ; Lipopolysaccharides - toxicity ; Male ; Miscarriage ; Physiological aspects ; Pregnancy ; Prevention ; Rats ; Rats, Wistar ; Tumor necrosis factor ; Tumor Necrosis Factor-alpha - blood</subject><ispartof>Mediators of Inflammation, 2013-01, Vol.2013 (2013), p.310-314</ispartof><rights>Copyright © 2013 Ayse Er.</rights><rights>COPYRIGHT 2013 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2013 Ayse Er. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a640t-5202b05aeb103f43bc2d016117a0ed426972d5549a7ce5bee1d0c0d193f9b45a3</citedby><cites>FETCH-LOGICAL-a640t-5202b05aeb103f43bc2d016117a0ed426972d5549a7ce5bee1d0c0d193f9b45a3</cites><orcidid>0000-0002-6900-0055</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859211/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859211/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24371377$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Skarzyński, Dariusz J.</contributor><creatorcontrib>Er, Ayse</creatorcontrib><title>Azithromycin Prevents Pregnancy Loss: Reducing the Level of Tumor Necrosis Factor-Alpha and Raising the Level of Interleukin-10 in Rats</title><title>Mediators of Inflammation</title><addtitle>Mediators Inflamm</addtitle><description>The aim of this study was to determine the effect of azithromycin on LPS-induced pregnancy loss. Thirty-six pregnant female Wistar rats were divided into 4 equal groups as follows: control group, where 0.3 mL of normal saline solution was administered intravenously on day 10 of pregnancy; azithromycin group, where azithromycin was administered orally at 350 mg kg−1 day on days 9, 10, and 11 of pregnancy; lipopolysaccharide group, where LPS was administered intravenously via the tail vein at 160 μg kg−1 on day 10 of pregnancy; and the azithromycin + LPS group, where azithromycin was administered orally at 350 mg kg−1 day on days 9, 10, and 11 of pregnancy and LPS was administered intravenously at 160 μg kg−1 on day 10 of pregnancy. Blood samples were obtained from the tail vein on day 10 of the experiment. Pregnancy rates were determined. Tumor necrosis factor-alpha (TNF-α) and interleukin (IL-10) levels were measured by ELISA. Azithromycin prevented (P&lt;0.05) LPS-induced pregnancy loss. Higher TNF-α and IL-10 levels were measured (P&lt;0.05) in the LPS and azithromycin + LPS groups, respectively. 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Higher TNF-α and IL-10 levels were measured (P&lt;0.05) in the LPS and azithromycin + LPS groups, respectively. In conclusion, azithromycin may be useful in infection- or endotoxemia-dependent pregnancy loss.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Limiteds</pub><pmid>24371377</pmid><doi>10.1155/2013/928137</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-6900-0055</orcidid><oa>free_for_read</oa></addata></record>
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source Wiley Open Access Journals; PubMed Central
subjects Abortion, Septic - immunology
Abortion, Septic - prevention & control
Animals
Anti-Bacterial Agents - therapeutic use
Azithromycin
Azithromycin - therapeutic use
Female
Health aspects
Interleukin-10
Interleukin-10 - blood
Lipopolysaccharides - toxicity
Male
Miscarriage
Physiological aspects
Pregnancy
Prevention
Rats
Rats, Wistar
Tumor necrosis factor
Tumor Necrosis Factor-alpha - blood
title Azithromycin Prevents Pregnancy Loss: Reducing the Level of Tumor Necrosis Factor-Alpha and Raising the Level of Interleukin-10 in Rats
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