The role of biomarkers in dilated cardiomyopathy: Assessment of clinical severity and reverse remodeling

Biomarkers in dilated cardiomyopathy (DCM) reflect various pathobiological processes, including neurohormonal activation, oxidative stress, matrix remodeling, myocyte injury and myocyte stretch. We assessed the role of biomarkers in clinical and echocardiographic parameters and in left ventricular (...

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Bibliographic Details
Published in:Revista portuguesa de cardiologia 2017-10, Vol.36 (10), p.709-716
Main Authors: Amorim, Sandra, Campelo, Manuel, Moura, Brenda, Martins, Elisabete, Rodrigues, João, Barroso, Isaac, Faria, Margarida, Guimarães, Tiago, Macedo, Filipe, Silva-Cardoso, José, Maciel, Maria Júlia
Format: Article
Language:English
Subjects:
Biomarcadores
Biomarkers
Biomarkers - blood
Cardiomyopathy, Dilated - blood
Cardiomyopathy, Dilated - diagnostic imaging
Dilated cardiomyopathy
Echocardiography
Female
Humans
Male
Middle Aged
Miocardiopatia dilatada
Prospective Studies
Remodelagem reversa
Reverse remodeling
Severity of Illness Index
Ventricular Remodeling
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Summary:Biomarkers in dilated cardiomyopathy (DCM) reflect various pathobiological processes, including neurohormonal activation, oxidative stress, matrix remodeling, myocyte injury and myocyte stretch. We assessed the role of biomarkers in clinical and echocardiographic parameters and in left ventricular (LV) reverse remodeling (LVRR). In this prospective study of 50 DCM patients (28 men, aged 59±10 years) with LV ejection fraction (LVEF) 10 U in LVEF after optimal medical therapy. Baseline LVEF was 25.4±9.8% and LV end-diastolic diameter (LVEDD)/body surface area (BSA) was 34.2±4.5 mm/m2. LVRR occurred in 34% of patients within 17.6±15.6 months. No correlation was found between B-type natriuretic peptide (BNP), 25-hydroxyvitamin D (25(OH)D), CA-125, high-sensitivity C-reactive protein (hs-CRP), lipoprotein(a) [Lp(a)], noradrenaline, adrenaline, renin or aldosterone and LVRR. Patients in NYHA class III or IV, with pulmonary congestion or ankle edema, had higher CA-125, cystatin C, BNP and hs-CRP levels (p
ISSN:0870-2551
2174-2030
DOI:10.1016/j.repc.2017.02.015