The Burden of Comorbidities in Obstructive Sleep Apnea and the Pathophysiologic Mechanisms and Effects of CPAP

Micro-arousals and the repeated desaturation of oxyhemoglobin, which are typical in obstructive sleep apnea syndrome (OSAS), have adverse effects on the health of patients, leading to a wide range of complications such as cardiovascular (arterial hypertension, pulmonary hypertension, chronic heart f...

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Bibliographic Details
Published in:Clocks & Sleep (Online) 2023-06, Vol.5 (2), p.333-349
Main Authors: Sircu, Victoria, Colesnic, Silvia-Iaroslava, Covantsev, Serghei, Corlateanu, Olga, Sukhotko, Anna, Popovici, Cristian, Corlateanu, Alexandru
Format: Article
Language:English
Subjects:
Airway management
Analysis
Angina pectoris
Arrhythmia
Blood pressure
Cardiac arrhythmia
Chronic kidney failure
Chronic obstructive pulmonary disease
Comorbidity
Continuous positive airway pressure
CPAP
Diabetes
diabetes mellitus
Health aspects
Heart attack
Heart attacks
Hypertension
Hypoxia
Insulin resistance
Ischemia
ischemic heart disease
Liver cirrhosis
Metabolic syndrome
Nervous system
OSAS
Oxidative stress
Oxyhemoglobin
Patients
Pulmonary hypertension
Quality of life
Review
Risk factors
Sleep apnea
Sleep apnea syndromes
stroke
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Summary:Micro-arousals and the repeated desaturation of oxyhemoglobin, which are typical in obstructive sleep apnea syndrome (OSAS), have adverse effects on the health of patients, leading to a wide range of complications such as cardiovascular (arterial hypertension, pulmonary hypertension, chronic heart failure, arrhythmias, myocardial infarction), cerebrovascular (strokes), metabolic (insulin resistance, obesity, diabetes mellitus, metabolic syndrome), gastrointestinal (non-alcoholic liver disease), urinary (chronic renal failure), and neuropsychiatric complications as well as a wide range of malignancies. These, in turn, have multilateral effects on familial, occupational, and social life, as well as increasing the risks of road traffic accidents and accidents at the workplace. Awareness, timely screening, and the prevention of complications play important roles in diagnosing and treating comorbid conditions. This review focuses on comorbidities in OSAS and the effect of Continuous Positive Airway Pressure (CPAP) therapy on their prognoses.
ISSN:2624-5175
2624-5175
DOI:10.3390/clockssleep5020025