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Vaginal Microbiome in Pregnant Women with and without Short Cervix
Cervical shortening is a recognised risk factor for pre-term birth. The vaginal microbiome plays an essential role in pregnancy and in maternal and foetal outcomes. We studied the vaginal microbiome in 68 women with singleton gestation and a cervical length ≤25 mm and in 29 pregnant women with a cer...
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| Published in: | Nutrients 2023-05, Vol.15 (9), p.2173 |
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| Main Authors: | , , , , , , |
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| container_issue | 9 |
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| container_title | Nutrients |
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| creator | Silvano, Angela Meriggi, Niccolò Renzi, Sonia Seravalli, Viola Torcia, Maria Gabriella Cavalieri, Duccio Di Tommaso, Mariarosaria |
| description | Cervical shortening is a recognised risk factor for pre-term birth. The vaginal microbiome plays an essential role in pregnancy and in maternal and foetal outcomes. We studied the vaginal microbiome in 68 women with singleton gestation and a cervical length ≤25 mm and in 29 pregnant women with a cervix >25 mm in the second or early third trimester. Illumina protocol 16S Metagenomic Sequencing Library Preparation was used to detail amplified 16SrRNA gene. Statistical analyses were performed in R environment.
was the phylum most represented in all pregnant women. The mean relative abundance of
and
was higher in women with a short cervix. Bacterial abundance was higher in women with a normal length cervix compared to the group of women with a short cervix. Nonetheless, a significant enrichment in bacterial taxa poorly represented in vaginal microbiome was observed in the group of women with a short cervix.
and
taxa usually found in aerobic vaginitis, were more common in women with a short cervix compared with the control group, while
and
were associated with a normal cervical length.
and
were associated with a short cervix. |
| doi_str_mv | 10.3390/nu15092173 |
| format | article |
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was the phylum most represented in all pregnant women. The mean relative abundance of
and
was higher in women with a short cervix. Bacterial abundance was higher in women with a normal length cervix compared to the group of women with a short cervix. Nonetheless, a significant enrichment in bacterial taxa poorly represented in vaginal microbiome was observed in the group of women with a short cervix.
and
taxa usually found in aerobic vaginitis, were more common in women with a short cervix compared with the control group, while
and
were associated with a normal cervical length.
and
were associated with a short cervix.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu15092173</identifier><identifier>PMID: 37432374</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>aerobic vaginitis ; Analysis ; Cervix ; Discriminant analysis ; Ethnicity ; Gardenerella vaginalis ; Genetic testing ; Lactobacillus ; Metagenomics ; microbiome ; Microbiomes ; Microbiota ; Pregnancy ; Pregnant women ; Premature birth ; Relative abundance ; Risk factors ; risk in pregnancy ; shortened cervix ; Statistical analysis ; Taxonomy ; Vagina ; Vaginitis ; Veganism ; White people</subject><ispartof>Nutrients, 2023-05, Vol.15 (9), p.2173</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-c2c66cc1fbb57161d5bcbfae8e1dbad8f3febdfbbdacefb2f9f92e220f5875db3</citedby><cites>FETCH-LOGICAL-c540t-c2c66cc1fbb57161d5bcbfae8e1dbad8f3febdfbbdacefb2f9f92e220f5875db3</cites><orcidid>0000-0002-7412-823X ; 0000-0002-0450-106X ; 0000-0002-6908-2169 ; 0000-0001-8248-929X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2812618851/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2812618851?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37432374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silvano, Angela</creatorcontrib><creatorcontrib>Meriggi, Niccolò</creatorcontrib><creatorcontrib>Renzi, Sonia</creatorcontrib><creatorcontrib>Seravalli, Viola</creatorcontrib><creatorcontrib>Torcia, Maria Gabriella</creatorcontrib><creatorcontrib>Cavalieri, Duccio</creatorcontrib><creatorcontrib>Di Tommaso, Mariarosaria</creatorcontrib><title>Vaginal Microbiome in Pregnant Women with and without Short Cervix</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Cervical shortening is a recognised risk factor for pre-term birth. The vaginal microbiome plays an essential role in pregnancy and in maternal and foetal outcomes. We studied the vaginal microbiome in 68 women with singleton gestation and a cervical length ≤25 mm and in 29 pregnant women with a cervix >25 mm in the second or early third trimester. Illumina protocol 16S Metagenomic Sequencing Library Preparation was used to detail amplified 16SrRNA gene. Statistical analyses were performed in R environment.
was the phylum most represented in all pregnant women. The mean relative abundance of
and
was higher in women with a short cervix. Bacterial abundance was higher in women with a normal length cervix compared to the group of women with a short cervix. Nonetheless, a significant enrichment in bacterial taxa poorly represented in vaginal microbiome was observed in the group of women with a short cervix.
and
taxa usually found in aerobic vaginitis, were more common in women with a short cervix compared with the control group, while
and
were associated with a normal cervical length.
and
were associated with a short cervix.</description><subject>aerobic vaginitis</subject><subject>Analysis</subject><subject>Cervix</subject><subject>Discriminant analysis</subject><subject>Ethnicity</subject><subject>Gardenerella vaginalis</subject><subject>Genetic testing</subject><subject>Lactobacillus</subject><subject>Metagenomics</subject><subject>microbiome</subject><subject>Microbiomes</subject><subject>Microbiota</subject><subject>Pregnancy</subject><subject>Pregnant women</subject><subject>Premature birth</subject><subject>Relative abundance</subject><subject>Risk factors</subject><subject>risk in pregnancy</subject><subject>shortened cervix</subject><subject>Statistical analysis</subject><subject>Taxonomy</subject><subject>Vagina</subject><subject>Vaginitis</subject><subject>Veganism</subject><subject>White people</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkltLHTEQx4O0qFhf_ACy4EspHJvLJrv7VOyhF8FSoRcfQy6TPTnsJprdte23b9Zj1VNMIBlmfvMPMxmEjgg-ZazBb8NEOG4oqdgO2qe4ogshSvbiib2HDodhjedV4UqwXbTHqpLRfOyj9z9V64Pqii_epKh97KHwobhM0AYVxuIqO0Lxy4-rQgV7Z8RpLL6tYhqLJaRb__sVeulUN8Dh_X2Afnz88H35eXHx9dP58uxiYXiJx4WhRghjiNOaV0QQy7XRTkENxGpla8ccaJujVhlwmrrGNRQoxY7XFbeaHaDzja6Nai2vk-9V-iOj8vLOEVMrVRq96UAaUgrCGsa4YaUpTUME15gTTXMHlOZZ691G63rSPVgDYUyq2xLdjgS_km28lQSTOrdxVnh9r5DizQTDKHs_GOg6FSBOg6Q1E7QRmIqMnvyHruOUctNnilBB6pqTR6pVuQIfXMwPm1lUnlVlQxkr6UydPkPlbaH3JgZwPvu3Et5sEvL3DkMC91AkwXKeIPk4QRk-ftqWB_TfvLC_yIq_kg</recordid><startdate>20230502</startdate><enddate>20230502</enddate><creator>Silvano, Angela</creator><creator>Meriggi, Niccolò</creator><creator>Renzi, Sonia</creator><creator>Seravalli, Viola</creator><creator>Torcia, Maria Gabriella</creator><creator>Cavalieri, Duccio</creator><creator>Di Tommaso, Mariarosaria</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-7412-823X</orcidid><orcidid>https://orcid.org/0000-0002-0450-106X</orcidid><orcidid>https://orcid.org/0000-0002-6908-2169</orcidid><orcidid>https://orcid.org/0000-0001-8248-929X</orcidid></search><sort><creationdate>20230502</creationdate><title>Vaginal Microbiome in Pregnant Women with and without Short Cervix</title><author>Silvano, Angela ; Meriggi, Niccolò ; Renzi, Sonia ; Seravalli, Viola ; Torcia, Maria Gabriella ; Cavalieri, Duccio ; Di Tommaso, Mariarosaria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-c2c66cc1fbb57161d5bcbfae8e1dbad8f3febdfbbdacefb2f9f92e220f5875db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>aerobic vaginitis</topic><topic>Analysis</topic><topic>Cervix</topic><topic>Discriminant analysis</topic><topic>Ethnicity</topic><topic>Gardenerella vaginalis</topic><topic>Genetic testing</topic><topic>Lactobacillus</topic><topic>Metagenomics</topic><topic>microbiome</topic><topic>Microbiomes</topic><topic>Microbiota</topic><topic>Pregnancy</topic><topic>Pregnant women</topic><topic>Premature birth</topic><topic>Relative abundance</topic><topic>Risk factors</topic><topic>risk in pregnancy</topic><topic>shortened cervix</topic><topic>Statistical analysis</topic><topic>Taxonomy</topic><topic>Vagina</topic><topic>Vaginitis</topic><topic>Veganism</topic><topic>White people</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silvano, Angela</creatorcontrib><creatorcontrib>Meriggi, Niccolò</creatorcontrib><creatorcontrib>Renzi, Sonia</creatorcontrib><creatorcontrib>Seravalli, Viola</creatorcontrib><creatorcontrib>Torcia, Maria Gabriella</creatorcontrib><creatorcontrib>Cavalieri, Duccio</creatorcontrib><creatorcontrib>Di Tommaso, Mariarosaria</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest - Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silvano, Angela</au><au>Meriggi, Niccolò</au><au>Renzi, Sonia</au><au>Seravalli, Viola</au><au>Torcia, Maria Gabriella</au><au>Cavalieri, Duccio</au><au>Di Tommaso, Mariarosaria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vaginal Microbiome in Pregnant Women with and without Short Cervix</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2023-05-02</date><risdate>2023</risdate><volume>15</volume><issue>9</issue><spage>2173</spage><pages>2173-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Cervical shortening is a recognised risk factor for pre-term birth. The vaginal microbiome plays an essential role in pregnancy and in maternal and foetal outcomes. We studied the vaginal microbiome in 68 women with singleton gestation and a cervical length ≤25 mm and in 29 pregnant women with a cervix >25 mm in the second or early third trimester. Illumina protocol 16S Metagenomic Sequencing Library Preparation was used to detail amplified 16SrRNA gene. Statistical analyses were performed in R environment.
was the phylum most represented in all pregnant women. The mean relative abundance of
and
was higher in women with a short cervix. Bacterial abundance was higher in women with a normal length cervix compared to the group of women with a short cervix. Nonetheless, a significant enrichment in bacterial taxa poorly represented in vaginal microbiome was observed in the group of women with a short cervix.
and
taxa usually found in aerobic vaginitis, were more common in women with a short cervix compared with the control group, while
and
were associated with a normal cervical length.
and
were associated with a short cervix.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37432374</pmid><doi>10.3390/nu15092173</doi><orcidid>https://orcid.org/0000-0002-7412-823X</orcidid><orcidid>https://orcid.org/0000-0002-0450-106X</orcidid><orcidid>https://orcid.org/0000-0002-6908-2169</orcidid><orcidid>https://orcid.org/0000-0001-8248-929X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | aerobic vaginitis Analysis Cervix Discriminant analysis Ethnicity Gardenerella vaginalis Genetic testing Lactobacillus Metagenomics microbiome Microbiomes Microbiota Pregnancy Pregnant women Premature birth Relative abundance Risk factors risk in pregnancy shortened cervix Statistical analysis Taxonomy Vagina Vaginitis Veganism White people |
| title | Vaginal Microbiome in Pregnant Women with and without Short Cervix |
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