Hordenine Protects Against Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting Inflammation

Acute lung injury (ALI) is a respiratory disease that leads to death in severe cases. Hordenine (Hor), a barley-derived natural product, has various biological activities, including anti-inflammatory, and anti-oxidation activities. We investigated the effect of Hor on lipopolysaccharide-induced ALI...

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Bibliographic Details
Published in:Frontiers in pharmacology 2021-09, Vol.12, p.712232-712232
Main Authors: Zhang, Xiyue, Du, Li, Zhang, Jinrong, Li, Chunyan, Zhang, Jie, Lv, Xuejiao
Format: Article
Language:English
Subjects:
acute lung injury
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hordenine
lipopolysaccharide
mitogen-activated protein kinase
Pharmacology
protein kinase B/nuclear factor-κB
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Summary:Acute lung injury (ALI) is a respiratory disease that leads to death in severe cases. Hordenine (Hor), a barley-derived natural product, has various biological activities, including anti-inflammatory, and anti-oxidation activities. We investigated the effect of Hor on lipopolysaccharide-induced ALI and its potential mechanism. The anti-inflammatory effects of Hor were detected using in vivo and in vitro models by enzyme-linked immunosorbent assay, real-time polymerase chain reaction, western blotting, and molecular docking simulations. Hor inhibited increases in the levels of inflammatory factors both in vivo and in vitro , and its anti-inflammatory effect inhibited activation of protein kinase B, nuclear factor-κB, and mitogen-activated protein kinase signaling. Hor alleviated lipopolysaccharide-induced ALI by inhibiting inflammatory cytokine increases in vivo and in vitro and shows potential for preventing inflammatory disease.
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2021.712232