Drug-Induced Myocardial Infarction: A Review of Pharmacological Triggers and Pathophysiological Mechanisms

Myocardial infarction (MI) is a significant cardiovascular event caused by the decrease in or complete cessation of blood flow to a portion of the myocardium. It can arise from a variety of etiological factors, including pharmacological triggers. This review aims to explore the diverse drugs and sub...

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Bibliographic Details
Published in:Journal of cardiovascular development and disease 2024-12, Vol.11 (12), p.406
Main Authors: Boarescu, Ioana, Boarescu, Paul-Mihai
Format: Article
Language:English
Subjects:
Anti-inflammatory agents
Anticoagulants (Medicine)
Antipsychotic drugs
Atherosclerosis
Biomarkers
Blood clot
Blood coagulation factors
Blood pressure
Cardiovascular disease
Coronary vessels
Development and progression
Drug therapy
drugs
Endothelium
Enzymes
Etoricoxib
Heart attack
Heart attacks
Hypertension
Inflammation
Ischemia
Kinases
myocardial infarction
Nonsteroidal anti-inflammatory drugs
Oxidative stress
pathophysiological mechanisms
Patients
pharmacological triggers
Physiology
Review
Smooth muscle
Thrombosis
Type 2 diabetes
Workloads
Citations: Items that this one cites
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Summary:Myocardial infarction (MI) is a significant cardiovascular event caused by the decrease in or complete cessation of blood flow to a portion of the myocardium. It can arise from a variety of etiological factors, including pharmacological triggers. This review aims to explore the diverse drugs and substances that might lead to drug-induced myocardial infarction, focusing on their mechanisms of action and the pathophysiological processes involved. Various established and emerging pharmacological agents that could elevate the risk of myocardial infarction, such as nonsteroidal anti-inflammatory drugs, hormonal therapies, anticoagulants, and antipsychotic medications, are discussed. The role of drug-induced endothelial dysfunction, coronary artery spasm, and thrombosis are presented in order to highlight the underlying mechanisms. This review emphasizes the need for increased awareness among healthcare professionals to mitigate the risks associated with different pharmacological therapies to improve patient outcomes.
ISSN:2308-3425
2308-3425
DOI:10.3390/jcdd11120406