Viral RNA Interactome: The Ultimate Researcher's Guide to RNA-Protein Interactions

RNA molecules in the cell are bound by a multitude of RNA-binding proteins (RBPs) with a variety of regulatory consequences. Often, interactions with these RNA-binding proteins are facilitated by the complex secondary and tertiary structures of RNA molecules. Viral RNAs especially are known to be he...

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Bibliographic Details
Published in:Viruses 2024-10, Vol.16 (11), p.1702
Main Authors: Hanson, Wesley A, Romero Agosto, Gabriel A, Rouskin, Silvi
Format: Article
Language:English
Subjects:
Adenoviruses
Analysis
Animals
Chikungunya virus
Dengue fever
Drug development
Genomes
HIV
Human immunodeficiency virus
Humans
Interactomes
Nucleic Acid Conformation
Protein Binding
Protein interaction
Proteins
Replication
Review
Ribonucleic acid
RNA
RNA chemical probing
RNA secondary structure
RNA viruses
RNA, Viral - chemistry
RNA, Viral - genetics
RNA, Viral - metabolism
RNA-binding protein
RNA-binding protein (RBP)
RNA-Binding Proteins - chemistry
RNA-Binding Proteins - metabolism
RNA-protein interactome
Severe acute respiratory syndrome coronavirus 2
Structure
Virus Replication
virus-host interactome
West Nile virus
Zika virus
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Summary:RNA molecules in the cell are bound by a multitude of RNA-binding proteins (RBPs) with a variety of regulatory consequences. Often, interactions with these RNA-binding proteins are facilitated by the complex secondary and tertiary structures of RNA molecules. Viral RNAs especially are known to be heavily structured and interact with many RBPs, with roles including genome packaging, immune evasion, enhancing replication and transcription, and increasing translation efficiency. As such, the RNA-protein interactome represents a critical facet of the viral replication cycle. Characterization of these interactions is necessary for the development of novel therapeutics targeted at the disruption of essential replication cycle events. In this review, we aim to summarize the various roles of RNA structures in shaping the RNA-protein interactome, the regulatory roles of these interactions, as well as up-to-date methods developed for the characterization of the interactome and directions for novel, RNA-directed therapeutics.
ISSN:1999-4915
1999-4915
DOI:10.3390/v16111702