Redox and proteolytic regulation of cardiomyocyte β1-adrenergic receptors – a novel paradigm for the regulation of catecholamine responsiveness in the heart

Conventional models view β 1 -adrenergic receptors (β 1 ARs) as full-length proteins that activate signaling pathways that influence contractile function and ventricular remodeling - and are susceptible to agonist-dependent desensitization. This perspective summarizes recent studies from my laborato...

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Bibliographic Details
Published in:Frontiers in immunology 2023-12, Vol.14, p.1306467-1306467
Main Author: Steinberg, Susan F.
Format: Article
Language:English
Subjects:
cardiomyocytes
elastase
Immunology
oxidative stress
proteolysis
β1-adrenergic receptors
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Summary:Conventional models view β 1 -adrenergic receptors (β 1 ARs) as full-length proteins that activate signaling pathways that influence contractile function and ventricular remodeling - and are susceptible to agonist-dependent desensitization. This perspective summarizes recent studies from my laboratory showing that post-translational processing of the β 1 -adrenergic receptor N-terminus results in the accumulation of both full-length and N-terminally truncated forms of the β 1 AR that differ in their signaling properties. We also implicate oxidative stress and β 1 AR cleavage by elastase as two novel mechanisms that would (in the setting of cardiac injury or inflammation) lead to altered or decreased β 1 AR responsiveness.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1306467